FB2026_02 , released June 18, 2026
Allele: Dmel\Ubi-p63E12c
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General Information
Symbol
Dmel\Ubi-p63E12c
Species
D. melanogaster
Name
FlyBase ID
FBal0294228
Feature type
allele
Associated gene
Dmel\Ubi-p63E
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Lu et al., 2013)

amorphic allele - molecular evidence

(Lu et al., 2013)
Mutagen
Delta2-3 transposase
(Lu et al., 2013)
Progenitor genotype
P{EPgy2}Ubi-p63EEY07341
(Lu et al., 2013)
Caused by aberration
Df(3L)Ubi-p63E12c
Cytology
Description

Imprecise excision of P{EPgy2}Ubi-p63EEY07341, resulting in a 2.2kb deletion removing the transcription start site of all four annotated mRNAs plus most of the 5'UTR, stopping at 34bp before the ATG. The promoter and first 583bp of coding sequence of the neighbouring Sc2 gene are also removed.

(Lu et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:3,901,793..3,903,993 [-]
Comment:

A deletion associated with the imprecise excision of P{EPgy2}Ubi-p63EEY07341, which removes the promoter region and transcription start sites of Ubi-p63E, stopping 34 bp before the ATG. It also removes the first 583 bp of coding sequence of adjacent gene Sc2.

(Lu et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In the presence of Sc2+tLa, to rescue the lethality caused by the lesion in Sc, Ubi-p63E12c flies are completely viable but male sterile and display a meiotic arrest phenotype.

      Ubi-p63E12c/Ubi-p63E23b flies and Ubi-p63E12c flies carrying the rescuing Sc2+tLa allele are fully viable, develop at a normal pace to adulthood and females are robustly fertile.

      Ubi-p63E12c male germ cell clones (in the presence of Sc2+tLa) are not observed at the spermatid stage. Instead, they accumulate as clonal cysts with chromatin condensation defects and fail to reach metaphase or breakdown their nucleolus, eventually degenerating.

      (Lu et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ubi-p63E12c is rescued by Ubi-p63E+tLa

      (Lu et al., 2013)

      Ubi-p63E23b/Ubi-p63E12c is rescued by Ubi-p63E+tLa

      (Lu et al., 2013)
      Comments

      Ubi-p63E+tLa completely rescues the meiotic arrest seen in Ubi-p63E12c/Ubi-p63E23b testes.

      Ubi-p63E+tLa completely rescues the meiotic arrest and male sterility of Ubi-p63E12c.

      (Lu et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Associated with: A lethal lesion in the neighbouring Sc2 gene.

      (Lu et al., 2013)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ubi-p63E12c
      magn12c
      (Lu et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)