FlyBase Allele Report: Dmel\Ubi-p63E[Z3-3969]

General Information

Symbol

Dmel\Ubi-p63E^Z3-3969

Species

D. melanogaster

Name

FlyBase ID

FBal0294225

Feature type

allele

Associated gene

Dmel\Ubi-p63E

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Lu et al., 2013)

Mutagen

ethyl methanesulfonate

(Lu et al., 2013)

Progenitor genotype

Cytology

Description

Sequencing from 1kb upstream of the start codon to the end of the first 5' ubiquitin unit, and from the beginning of the last 3' ubiquitin to 580bp after the stop codon failed to identify any mutations in these regions. (Ten tandem copies of the Ub monomer sequence prevents sequencing of the poly-ubiquitin coding region.)

(Lu et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | male limited (with Ubi-p63E^12c)

(Lu et al., 2013)

abnormal meiotic cell cycle | male limited (with Ubi-p63E^23b)

(Lu et al., 2013)

abnormal meiotic cell cycle | male limited (with Ubi-p63E^EY07341)

(Lu et al., 2013)

abnormal meiotic cell cycle | male limited (with Ubi-p63E^Z3-2534)

(Lu et al., 2013)

abnormal meiotic cell cycle | male limited (with Ubi-p63E^Z3-4216)

(Lu et al., 2013)

abnormal meiotic cell cycle | male limited (with Ubi-p63E^Z3-5802)

(Lu et al., 2013)

male sterile

(Lu et al., 2013)

viable

(Lu et al., 2013)

Phenotype Manifest In

testis (with Ubi-p63E^12c)

(Lu et al., 2013)

testis (with Ubi-p63E^23b)

(Lu et al., 2013)

testis (with Ubi-p63E^EY07341)

(Lu et al., 2013)

testis (with Ubi-p63E^Z3-2534)

(Lu et al., 2013)

testis (with Ubi-p63E^Z3-4216)

(Lu et al., 2013)

testis (with Ubi-p63E^Z3-5802)

(Lu et al., 2013)

Detailed Description

Statement

Reference

In the testis of males transheterozygous for Ubi-p63E^Z3-3969 and Ubi-p63E^Z3-4216, Ubi-p63E^Z3-2534 or Ubi-p63E^Z3-5802, germ cells develop into mature spermatocytes but cell cycle progression is blocked prior to entering the first meiotic division.

(Lu et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ubi-p63E^Z3-3969 is rescued by Ubi-p63E^+tLa

(Lu et al., 2013)

Comments

Ubi-p63E^+tLa completely rescues the meiotic arrest and male sterility of Ubi-p63E^Z3-3969.

(Lu et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ubi-p63E^Z3-3969

magn^Z3-3969

(Lu et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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