FlyBase Allele Report: Dmel\Ubi-p63E[EY07341]

General Information

Symbol

Dmel\Ubi-p63E^EY07341

Species

D. melanogaster

Name

FlyBase ID

FBal0159570

Feature type

allele

Associated gene

Dmel\Ubi-p63E

Associated Insertion(s)

P{EPgy2}Ubi-p63E^EY07341

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lu et al., 2013)

hypomorphic allele - molecular evidence

(Lu et al., 2013)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Ubi-p63E^EY07341

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:3,902,949..3,902,949 [-]

(Kovács et al., 2020, Lu et al., 2013, Munoz-Soriano et al., 2012, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

testis (with Df(3L)Exel6098)

(Lu et al., 2013)

testis (with Ubi-p63E^Z3-2534)

(Lu et al., 2013)

testis (with Ubi-p63E^Z3-3969)

(Lu et al., 2013)

testis (with Ubi-p63E^Z3-4216)

(Lu et al., 2013)

testis (with Ubi-p63E^Z3-5802)

(Lu et al., 2013)

Detailed Description

Statement

Reference

Ubi-p63E^EY07341 males have elongated spermatids similar to controls.

(Kovács et al., 2020)

Homozygotes do not show meiotic arrest. Male germ cells progress through meiosis and spermatid elongation but do not produce functional sperm.

(Lu et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ubi-p63E^EY07341, Usp14^Δ32 has abnormal meiotic cell cycle | male | adult stage phenotype

(Kovács et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

Ubi-p63E^EY07341 is an enhancer of testis phenotype of Usp14^Δ32

(Kovács et al., 2020)

NOT Enhancer of

Statement

Reference

Ubi-p63E[+]/Ubi-p63E^EY07341 is a non-enhancer of wing phenotype of Scer\GAL4^da.G32, Septin4^UAS.cMa

(Munoz-Soriano et al., 2012)

Other

Statement

Reference

Ubi-p63E^EY07341, Usp14^Δ32 has spermatocyte phenotype

(Kovács et al., 2020)

Ubi-p63E^EY07341, Usp14^Δ32 has elongation stage spermatid phenotype

(Kovács et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Usp14^Δ32 Ubi-p63E^EY07341 double mutants exhibit arrested meiosis in spermatocytes while they do not exhibit any postmeiotic or elongated spermatocytes when compared to controls.

(Kovács et al., 2020)

Heterozygosity for Ubi-p63E^EY07341 does not enhance the wing phenotype caused by expression of two copies of Sep4^Scer\UAS.cMa under the control of Scer\GAL4^da.G32.

(Munoz-Soriano et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ubi-p63E^EY07341 is rescued by Ubi-p63E^+tLa

(Lu et al., 2013)

Comments

Ubi-p63E^+tLa completely rescues the male sterility of Ubi-p63E^Z3-5802.

(Lu et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

16814

y¹ w^67c23; P{EPgy2}Ubi-p63E^EY07341

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ubi-p63E^EY07341

(Ribot et al., 2022)

Ubi-p63E^EY

(Kovács et al., 2020)

magn^EP-ubi63E

(Lu et al., 2013)

magn^EP

(Lu et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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