Homozygous Atg17d130 mutants are pharate adult lethal. Escapers are very rarely seen in Atg17d130 hemizygotes.
Atg17d130 somatic clones exhibit severely impaired autophagosome formation.
Autophagosomes and autolysosomes are absent from the fat bodies of starved Atg17d130 mutant larvae.
Loss of Atg17 in Atg17d130 mutants blocks developmental autophagy in fat body cells and impairs programmed elimination of larval salivary glands during metamorphosis.