Open Close
General Information
Symbol
Dmel\Hsepid12
Species
D. melanogaster
Name
FlyBase ID
FBal0294779
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of HsepiKG02877 results in deletion of exon 1 and most of exon 2 of Hsepi.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Lethality of Hsepid12 homozygotes (18.3%) is equivalent to that of their deficiency transheterozygotes (Hsepid12/Df(2R)cn88b; 19.3%), indicating that this is a null allele.

Hsepid12 adult survivors show only modest morphological phenotypes, such as extra vein materials at the posterior crossvein region of the wing. The penetrance of this phenotype is 25% in males and 90% in females. This phenotype is also observed in Hsepid12/Hsepid13 transallelic mutants.

Despite the relatively normal development and fertility of Hsepid12 adult survivors, the longevity of mutant adults is remarkably shorter than wild-type. The median of adult longevity of Hsepid12 mutants is 27 days, whereas it is 63 days in wild-type.

Hsepid12 mutant ovarioles show the same number of stalk cells as in wild-type.

The overall morphology of Hsepid12 mutant testes is normal.

No abnormality is observed in longitudinal wing vein structures of Hsepid12 homozygous mutant flies.

No defects are found in tracheoblasts in Hsepid12 mutant wing discs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Hsepid12 has wing vein phenotype, enhanceable by sfl[+]/sfl03844

Hsepid12 has wing vein L5 phenotype, enhanceable by sfl[+]/sfl03844

Suppressed by
Statement
Reference

Hsepid12 has wing sensillum phenotype, suppressible by dlp1/dlp[+]

Hsepid12 has wing sensillum phenotype, suppressible by Sdc48/Sdc[+]

Hsepid12 has wing vein L5 phenotype, suppressible by Hs6st[+]/Hs6std770

NOT Suppressor of
Statement
Reference

Hsepid12 is a non-suppressor of stalk follicle cell phenotype of Hs2std267

Hsepid12 is a non-suppressor of ovariole phenotype of Hs2std267

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Hs2std267 Hsepid12 double mutants exhibit an ovariole stalk cell phenotype similar to that in Hs2std267 single mutants.

A heterozygous dallygem mutant in a Hsepid12 homozygous background results in a decreased number of chemosensory bristles.

A heterozygous dlp1 or Sdc48 background does not result in a decreased number of chemosensory bristles in Hsepid12 homozygous mutants.

Hsepid12; dallygem double mutants are lethal.

Heterozygous sfl03844 mutants in a Hsepid12 mutant background exhibit truncation of the longitudinal vein L5.

Hsepid12/Hsepid12; Hs6std770/+ mutants show a reduction of the wing vein L5.

Knockdown of Hs6st through expression of Hs6stGD3078 under the control of Scer\GAL4btl.PS at 25[o]C in a Hs2std267 Hsepid12 double mutant background severely interferes with tracheoblast formation.

Knockdown of Hs6st through expression of Hs6stGD3078 under the control of Scer\GAL4btl.PS at 25[o]C in a Hsepid12 mutant background severely interferes with tracheoblast formation

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)