FlyBase Allele Report: Dmel\Moe[ΔACT.UAS.Tag:MYC]

General Information

Symbol

Dmel\Moe^{ΔACT.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0295011

Feature type

allele

Associated gene

Dmel\Moe

Associated Insertion(s)

Carried in Construct

P{UAS-Moe.myc.ΔACT}

Key Links

Transgenic product class

inframe_deletion

(Neisch et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Neisch et al., 2013)

Mutagen

in vitro construct

(Neisch et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-Moe.myc.ΔACT}

Cytology

Description

UAS regulates expression of Moe minus the last 34 amino acids from the C-terminus, tagged with Tag:MYC.

(Neisch et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Moe

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing disc, with Scer\GAL4^ap-md544

(Neisch et al., 2013)

Detailed Description

Statement

Reference

Scer\GAL4^ap-md544-mediated expression of conu^{Scer\UAS.T:Zzzz\FLAG} results in ectopic folding of the wing disc epithelium.

(Neisch et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Moe^{ΔACT.UAS.Tag:MYC}, Scer\GAL4^ap-md544, conu^UAS.Tag:FLAG has neoplasia phenotype

(Neisch et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Moe^{ΔACT.UAS.Tag:MYC}, Scer\GAL4^ap-md544 has wing disc phenotype, enhanceable by conu^UAS.Tag:FLAG, Scer\GAL4^ap-md544

(Neisch et al., 2013)

Suppressed by

Statement

Reference

Moe^{ΔACT.UAS.Tag:MYC}, Scer\GAL4^ap-md544 has wing disc phenotype, suppressible by conu^RNAi.UAS.1/conu^RNAi.UAS.2, Scer\GAL4^ap-md544

(Neisch et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of conu^{Scer\UAS.T:Zzzz\FLAG} in a Scer\GAL4^ap-md544 conu^{Scer\UAS.T:Zzzz\FLAG} background leads to overgrowth and more severe folding of the wing disc epithelium.

Co-expression of conu^{dsRNA.Scer\UAS.1} and conu^{dsRNA.Scer\UAS.2} suppresses the ectopic folding of the wing disc seen in a Scer\GAL4^ap-md544 conu^{Scer\UAS.T:Zzzz\FLAG} background.

(Neisch et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

600554

w^*; P{UAS-Moe.myc.ΔACT}3/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Moe^{ΔACT.Scer\UAS.T:Hsap\MYC}

Moe^{ΔACT.UAS.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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