FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PGRP-SC2UAS.cGa
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General Information
Symbol
Dmel\PGRP-SC2UAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Guo
FlyBase ID
FBal0295023
Feature type
allele
Associated gene
Dmel\PGRP-SC2
Associated Insertion(s)
Carried in Construct
P{UAS-PGRP-SC2.G}
Also Known As
UAS-PGRP-SC2
Key Links
Transgenic product class
wild_type
(Guo et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Guo et al., 2014)
Mutagen
in vitro construct
(Guo et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-PGRP-SC2.G}
Cytology
Description

UAS regulatory sequences drive expression of PGRP-SC2.

(Guo et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
PGRP-SC2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by yki3SA.lexAop.Tag:Myr(Unk),GFP
      (Chen et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      30 day old flies expressing PGRP-SC2Scer\UAS.cGa under the control of Scer\GAL4Myo31DF-NP0001 in the enterocytes show a significant reduction in the numbers of commensal bacteria in the gut compared to age-matched controls. Intestinal stem cell proliferation is significantly reduced in the 30 day old mutant flies compared to controls.

      50-day old flies expressing PGRP-SC2Scer\UAS.cGa under the control of Scer\GAL4GSG5966 (in the presence of RU486) show a significant reduction in the numbers of commensal bacteria in the gut compared to age-matched controls. Intestinal stem cell proliferation is significantly reduced in the 30 day old mutant flies compared to controls.

      Expression of PGRP-SC2Scer\UAS.cGa under the control of Scer\GAL4Myo31DF-NP0001 results in a significant increase in median lifespan compared to controls under conventional culture conditions.

      Expression of PGRP-SC2Scer\UAS.cGa under the control of Scer\GAL4GSG5966 during the adult stage (using RU486 to control the timing of expression) results in a significant increase in median lifespan compared to controls under conventional culture conditions results. This increased lifespan is strongly reduced if the flies are reared under axenic conditions.

      (Guo et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      30 day adults co-expressing foxoKK108485 and PGRP-SC2Scer\UAS.cGa under the control of Scer\GAL4Myo31DF-NP0001 in the enterocytes do not show a reduction in intestinal stem cell proliferation compared to age-matched controls.

      (Guo et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PGRP-SC2Scer\UAS.cGa
      PGRP-SC2UAS.cGa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Guo
      Secondary FlyBase IDs
        References (2)