FlyBase Allele Report: Dmel\hep[Act.UAS.cUa]

General Information

Symbol

Dmel\hep^Act.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0295571

Feature type

allele

Associated gene

Dmel\hep

Associated Insertion(s)

Carried in Construct

P{UAS-hep.Act.U}

Also Known As

UAS-Hep^Act, UAS-hep^CA, hep^Act

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-hep.Act.U}

Cytology

Description

UAS regulatory sequences drive expression of a constitutively active form of hep.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

hep

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Tare et al., 2011)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Irwin et al., 2020)

modeled by Hsap\APP^2xAPP.SP.UAS

(Sarkar et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^GMR.PU

(Tare et al., 2011)

visible, with Scer\GAL4^GMR.PU

(Tare et al., 2011)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Tare et al., 2011)

eye disc, with Scer\GAL4^GMR.PU

(Tare et al., 2011)

Detailed Description

Statement

Reference

Animals expressing hep^{Act.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU show increased cell death seen in the third larval instar eye disc and adults have a small eye.

(Tare et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

hep^Act.UAS.cUa, Scer\GAL4^GMR.PU is an enhancer of increased cell death phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU

(Tare et al., 2011)

hep^Act.UAS.cUa, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

hep^Act.UAS.cUa, Scer\GAL4^GMR.PU is an enhancer of eye disc phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU

(Tare et al., 2011)

hep^Act.UAS.cUa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of hep^{Act.Scer\UAS.cUa} enhances the increase in cell death seen in the third larval instar eye disc of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU and results in adults having a "no-eye" phenotype.

(Tare et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Hep^CA

(Chen et al., 2020)

hep^{Act.Scer\UAS.cUa}

hep^Act.UAS.cUa

hep^Act

(Tare et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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