FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\drprII.UAS
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General Information
Symbol
Dmel\drprII.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0295663
Feature type
allele
Associated gene
Dmel\drpr
Associated Insertion(s)
Carried in Construct
P{UAS-drpr.II}
Key Links
Transgenic product class
cDNA
(Logan et al., 2012)
wild_type
(Logan et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Logan et al., 2012)
wild_type
(Logan et al., 2012)
Mutagen
in vitro construct
(Logan et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-drpr.II}
Cytology
Description

UASt regulatory sequences drive expression of isoform II of drpr (corresponding to GH03529).

(Logan et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
drpr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of drprII.Scer\UAS in glia cells (under the control of Scer\GAL4repo completely blocks glial clearance of axonal debris.

      Co-expression of drprI.Scer\UAS and drprII.Scer\UAS in glial cells, under the control of Scer\GAL4repo partially suppresses clearance of axonal debris.

      (Logan et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A csw5 heterozygous mutant background completely suppresses the blocked severed axon debris engulfment seen in flies expressing drprII.Scer\UAS in glial cells under the control of Scer\GAL4repo.

      Co-expression of cswGD11171 in glial cells (under the control of Scer\GAL4repo) significantly suppresses the inhibitory activity of drprII.Scer\UAS expression on glial clearance of axonal debris.

      (Logan et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      drprII.UAS/Scer\GAL4repo fails to rescue drprΔ5

      (Logan et al., 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      drprII.Scer\UAS
      drprII.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)