FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\AK1UAS.cPa
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General Information
Symbol
Hsap\AK1UAS.cPa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Park
FlyBase ID
FBal0295945
Feature type
allele
Associated gene
Hsap\AK1
Associated Insertion(s)
Carried in Construct
P{UAS-AK1.P}
Key Links
Transgenic product class
wild_type
(Park et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Park et al., 2012)
Mutagen
in vitro construct
(Park et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-AK1.P}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\AK1.

(Park et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\AK1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Park et al., 2012)
      modeled by Hsap\MAPTUAS.cWa
      (Park et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      There is no obvious difference between the eyes of flies expressing Hsap\AK1Scer\UAS.cPa under the control of Scer\GAL4GMR.PU compared to controls.

      Flies expressing Hsap\AK1Scer\UAS.cPa under the control of Scer\GAL4elav.PU have a similar lifespan to controls.

      (Park et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Hsap\AK1UAS.cPa, Scer\GAL4GMR.PU is an enhancer of eye phenotype of Hsap\MAPTGMR.Ex.PJ, Scer\GAL4GMR.PU

      (Park et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\AK1Scer\UAS.cPa enhances the rough eye phenotype seen when Hsap\MAPTGMR.Ex.PJ is expressed under the control of Scer\GAL4GMR.PU.

      Expression of Hsap\AK1Scer\UAS.cPa enhances the reduced lifespan seen when Hsap\MAPTScer\UAS.cWa is expressed pan-neuronally under the control of Scer\GAL4elav.PU.

      (Park et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\AK1Scer\UAS.cPa
      Hsap\AK1UAS.cPa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Park
      Secondary FlyBase IDs
        References (1)