FlyBase Allele Report: Dmel\SelR[UAS.cHa]

General Information

Symbol

Dmel\SelR^UAS.cHa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Hung

FlyBase ID

FBal0296072

Feature type

allele

Associated gene

Dmel\SelR

Associated Insertion(s)

Carried in Construct

P{UAS-SelR.H}

Also Known As

UAS:SelR

Key Links

Transgenic product class

wild_type

(Hung et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Hung et al., 2013)

Mutagen

in vitro construct

(Hung et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-SelR.H}

Cytology

Description

UASt regulates expression of SelR.

(Hung et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

SelR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav.PU

(Hung et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^how-24B- or Scer\GAL4^Mef2.PR-mediated expression of SelR^Scer\UAS.cHa results in abnormal actin accumulations in larval muscles.

Scer\GAL4^elav.PU-mediated expression of SelR^Scer\UAS.cHa results in axon guidance defects in ISNb, characterized by decreased axonal defasciculation/repulsion and a failure of axons to reach their correct targets, and synaptogenic defects, with a decreased length of synaptic innervation.

(Hung et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

SelR^UAS.cHa, Scer\GAL4^Act5C.PI is a suppressor of lethal phenotype of Mical^UAS.s, Scer\GAL4^Act5C.PI

(Hung et al., 2013)

SelR^UAS.cHa, Scer\GAL4^how-24B is a suppressor of lethal phenotype of Mical^UAS.s, Scer\GAL4^how-24B

(Hung et al., 2013)

SelR^UAS.cHa, Scer\GAL4^Act5C.PI is a suppressor of lethal phenotype of Mical^{redoxCH.UAS.Tag:polyHis}, Scer\GAL4^Act5C.PI

(Hung et al., 2013)

SelR^UAS.cHa, Scer\GAL4^how-24B is a suppressor of lethal phenotype of Mical^{redoxCH.UAS.Tag:polyHis}, Scer\GAL4^how-24B

(Hung et al., 2013)

SelR^UAS.cHa, Scer\GAL4^elav.PU is a suppressor of abnormal neuroanatomy phenotype of PlexA^UAS.cWa, Scer\GAL4^elav.PU

(Hung et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

SelR^UAS.cHa, Scer\GAL4^B11-98 is a suppressor of macrochaeta phenotype of Mical^UAS.s, Scer\GAL4^B11-98

(Hung et al., 2013)

SelR^UAS.cHa, Scer\GAL4^B11-98 is a suppressor of filamentous actin phenotype of Mical^UAS.s, Scer\GAL4^B11-98

(Hung et al., 2013)

SelR^UAS.cHa, Scer\GAL4^how-24B is a suppressor of larval somatic muscle cell | third instar larval stage phenotype of Mical^UAS.s, Scer\GAL4^how-24B

(Hung et al., 2013)

SelR^UAS.cHa, Scer\GAL4^elav.PU is a suppressor of central nervous system phenotype of PlexA^UAS.cWa, Scer\GAL4^elav.PU

(Hung et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of SelR^Scer\UAS.cHa strongly suppresses the branched bristle phenotype seen upon Scer\GAL4^B11-98-mediated expression of Mical^Scer\UAS.s.

Co-expression of SelR^Scer\UAS.cHa suppresses the actin alterations seen within bristles upon Scer\GAL4^B11-98-mediated expression of Mical^Scer\UAS.s.

Co-expression of SelR^Scer\UAS.cHa suppresses the actin organization defects seen in larval muscles of Scer\GAL4^how-24B Mical^Scer\UAS.s animals.

Scer\GAL4^elav.PU-mediated expression of SelR^Scer\UAS.cHa significantly rescues the axon guidance defects seen in SelR^Scer\UAS.cHa Scer\GAL4^elav.PU animals.

(Hung et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^B11-98/SelR^UAS.cHa rescues Df(3R)SelR^Delta3

(Hung et al., 2013)

Scer\GAL4^elav.PU/SelR^UAS.cHa rescues Df(3R)SelR^Delta3/Df(3R)Exel7305

(Hung et al., 2013)

Comments

Scer\GAL4^B11-98-mediated expression of SelR^Scer\UAS.cHa rescues the branched bristles defects of Df(3R)SelR^Delta3 homozygotes.

Scer\GAL4^elav.PU-mediated expression of SelR^Scer\UAS.cHa significantly rescues the ISNb and SNa axon guidance defects in Df(3R)Exel7305/Df(3R)SelR^Delta3 animals.

(Hung et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

SelR^Scer\UAS.cHa

SelR^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Hung

Secondary FlyBase IDs

References (2)

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