FB2026_02 , released June 18, 2026
Allele: Dmel\brpΔ190
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General Information
Symbol
Dmel\brpΔ190
Species
D. melanogaster
Name
FlyBase ID
FBal0296087
Feature type
allele
Associated gene
Dmel\brp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Matkovic et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement resulting in a premature stop codon at residue 261 of the brp-190 protein isoform.

(Matkovic et al., 2013)

Amino acid replacement: Q261term.

(Matkovic et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,511,063..9,511,063 [+]
Nucleotide change:

C9511063T

Amino acid change:

Q261term | brp-PD; Q261term | brp-PE; Q307term | brp-PG; Q261term | brp-PH; Q307term | brp-PJ; Q307term | brp-PK; Q307term | brp-PL; Q261term | brp-PM; Q307term | brp-PN; Q261term | brp-PO; Q307term | brp-PP; Q307term | brp-PQ; Q307term | brp-PR

Reported amino acid change:

Q261term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Matkovic et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      brpΔ190/brp69 and brpΔ190/Df(2R)brp6.1 flies have reduced fitness and eclosion rates compared to controls.

      Mean T-bar height, mean T-bar platform width and mean T-bar pedestal width are significantly reduced in the active zones of mutant third instar larvae compared to wild type.

      The mean evoked excitatory junctional current (eEJC) amplitude at the neuromuscular junction is reduced compared to wild type in mutant third instar larvae, while eEJC rise time and decay are not significantly different from normal. The frequency, mean amplitude, rise time and decay of the spontaneous mEJC are also not significantly different from wild type in the mutant larvae.

      (Matkovic et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BRPΔ190
      (Ghelani et al., 2023)
      brpΔ190
      (Driller et al., 2019, Matkovic et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)