FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Vps11LL06553
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General Information
Symbol
Dmel\Vps11LL06553
Species
D. melanogaster
Name
FlyBase ID
FBal0296360
Feature type
allele
Associated gene
Dmel\Vps11
Associated Insertion(s)
PBac{SAstopDsRed}LL06553
Carried in Construct
Also Known As
Vps11[LL06553], Vps11LL
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{SAstopDsRed}LL06553
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{SAstopDsRed}
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Vps11LL06553 garland cells show increased numbers of autophagosomes (endogenous Atg8a-positive puncta), as compared to controls.

        (Lőrincz et al., 2019)

        Vps11LL06553/Vps11LL06553 mutant larvae do not exhibit hemocyte-derived melanotic tumors, but do exhibit enlargement of late endosomes and enlarged vacuoles with multiple dense cores in garland nephrocytes, as compared to controls.

        (Lőrincz et al., 2016)

        Autolysosome formation is inhibited in the fat body cells of starved CG32350LL06553 mutant wandering third instar larvae. Large number of autophagosomes are observed. Numerous dense organelles are seen, which are usually round and smaller than the autolysosomes observed in controls. A subset of these vesicles contain recognisable remnants of cytoplasmic material, such as mitochondrion.

        (Takáts et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (7)
        Reported As
        Symbol Synonym
        CG32350LL06553
        (Takáts et al., 2015)
        Vps11LL06553
        Vps11LL
        (Lőrincz et al., 2016, Takáts et al., 2014)
        Vps11[LL06553]
        (Boda et al., 2019, Nagy et al., 2015, Takáts et al., 2014)
        Vps11[LL]
        (Boda et al., 2019)
        vps11LL06553
        (Lőrincz et al., 2019, Lőrincz et al., 2016)
        vps11LL
        (Lőrincz et al., 2019)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)