FB2025_01 , released February 20, 2025
Allele: Dmel\cpaΔABD.UAS.Tag:HA
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General Information
Symbol
Dmel\cpaΔABD.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0296591
Feature type
allele
Associated gene
Dmel\cpa
Associated Insertion(s)
Carried in Construct
P{UAS-HA-cpa.ΔABD}
Key Links
Transgenic product class
inframe_deletion
(Fernández et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Fernández et al., 2014)
Mutagen
in vitro construct
(Fernández et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-HA-cpa.ΔABD}
Cytology
Description

UAS regulatory sequences drive expression of cpa coding sequences where the C-terminal actin-binding domain is deleted, and tagged at the N-terminal with Tag:HA.

(Fernández et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cpa
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of ZyxScer\UAS.T:Myr-Src42A and cpaΔABD.Scer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa under the control of Scer\GAL4nub.PU results in severely malformed adult wings that are not observed when either ZyxScer\UAS.T:Myr-Src42A is expressed alone or cpaΔABD.Scer\UAS.T:Ivir\HA1 is co-expressed with cpbScer\UAS.cWa only.

      The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for animals expressing ZyxScer\UAS.T:Myr-Src42A under the control of Scer\GAL4GMR.PU can be enhanced by co-expression with cpaΔABD.Scer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa.

      (Gaspar et al., 2015)

      Co-expression of cpaΔABD.Scer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa under the control of Scer\GAL4hh-Gal4 does not suppress apoptosis nor restore tissue growth in imaginal wing discs expressing Src64BUY1332 under the control of Scer\GAL4sd-SG29.1.

      Co-expression of cpaΔABD.Scer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa under the control of Scer\GAL4hh-Gal4 results in ectopic F-actin formation in the posterior compartment of the imaginal wing disc.

      (Fernández et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cpaΔABD.Scer\UAS.T:Ivir\HA1
      cpaΔABD.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)