FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cpbUAS.cWa
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General Information
Symbol
Dmel\cpbUAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0180369
Feature type
allele
Associated gene
Dmel\cpb
Associated Insertion(s)
Carried in Construct
P{UAS-cpb.W}
Also Known As
UAS-cpb
Key Links
Transgenic product class
cDNA
(Whited et al., 2004)
wild_type
(Whited et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Whited et al., 2004)
wild_type
(Whited et al., 2004)
Mutagen
in vitro construct
(Whited et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-cpb.W}
Cytology
Description

UAS sequences control expression of full length cpb cDNA (SD07714).

(Whited et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cpb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of cpbScer\UAS.cWa under the control of Scer\GAL4hh-Gal4 does not affect F-actin polymerisation.

      (Fernández et al., 2014)

      Expression of cpbScer\UAS.cWa under the control of Scer\GAL4slbo.2.6 results in premature arrival of the border cells at the oocyte.

      (Gates et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased adult wing size due to expression of ZyxScer\UAS.T:Myr-Src42A under the control of Scer\GAL4nub.PU can be partially suppressed by co-expression of cpaScer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa.

      Co-expression of ZyxScer\UAS.T:Myr-Src42A and cpaΔABD.Scer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa under the control of Scer\GAL4nub.PU results in severely malformed adult wings that are not observed when either ZyxScer\UAS.T:Myr-Src42A is expressed alone or cpaΔABD.Scer\UAS.T:Ivir\HA1 is co-expressed with cpbScer\UAS.cWa only.

      The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for animals expressing ZyxScer\UAS.T:Myr-Src42A under the control of Scer\GAL4GMR.PU can be enhanced by co-expression with cpaΔABD.Scer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa.

      Co-expression of cpaScer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa under the control of Scer\GAL4nub.PU leads to significantly reduced adult wing size compared to controls.

      (Gaspar et al., 2015)

      Co-expression of cpaScer\UAS.N.T:Ivir\HA1 and cpbScer\UAS.cWa in imaginal wing discs, under the control of Scer\GAL4sd-SG29.1 results in very low apoptotic levels and no significant growth defects compared to control discs.

      Co-expression of cpaScer\UAS.N.T:Ivir\HA1 and cpbScer\UAS.cWa appears to significantly suppress apoptosis and to restore tissue growth in imaginal wing discs expressing Src64BUY1332 under the control of Scer\GAL4sd-SG29.1.

      Co-expression of cpaScer\UAS.N.T:Ivir\HA1 and cpbScer\UAS.cWa in Rho1N19.Scer\UAS overexpressing wing discs (all under the control of Scer\GAL4sd-SG29.1) restores tissue growth and suppresses Mmp1 accumulation, as found in wing discs expressing Rho1N19.Scer\UAS alone. However, co-expression of cpaScer\UAS.N.T:Ivir\HA1 and cpbScer\UAS.cWa does not affect growth or ectopic Mmp1 expression.

      Co-expression of cpaScer\UAS.N.T:Ivir\HA1 and cpbScer\UAS.cWa under the control of Scer\GAL4hh-Gal4 reduces apical F-actin levels in the posterior compartment of the imaginal wing disc.

      Co-expression of cpaΔABD.Scer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa under the control of Scer\GAL4hh-Gal4 does not suppress apoptosis nor restore tissue growth in imaginal wing discs expressing Src64BUY1332 under the control of Scer\GAL4sd-SG29.1.

      Co-expression of cpaΔABD.Scer\UAS.T:Ivir\HA1 and cpbScer\UAS.cWa under the control of Scer\GAL4hh-Gal4 results in ectopic F-actin formation in the posterior compartment of the imaginal wing disc.

      (Fernández et al., 2014)

      Overexpression of cpbScer\UAS.cWa is able to fully suppress the migration defect and F-actin polarisation defects of wtsx1 mutant border cell clusters.

      (Lucas et al., 2013)

      Overexpression of cpbScer\UAS.cWa under the control of Scer\GAL415J2 enhances the early longitudinal axon phenotype of Nl1N-ts1.

      (Kuzina et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference

      While expression of BacA\p35GMR.PH in imaginal wing discs expressing Src64BUY1332 under the control of Scer\GAL4sd-SG29.1 increases disc size up to 2.5 times (compared to controls), co-expression of cpaScer\UAS.N.T:Ivir\HA1 and cpbScer\UAS.cWa in these tissues significantly reduces tissue growth to 1.8 times that found in controls, but does not affect growth of Scer\GAL4sd-SG29.1-->BacA\p35GMR.PH wing discs.

      (Fernández et al., 2014)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cpbScer\UAS.cWa
      cpbUAS.cWa
      Name Synonyms
      Secondary FlyBase IDs
        References (8)