sgll⁹⁵ homozygous mutant adults all die with 5 d on a sugar-only diet; under these conditions, they perform seizure-like behavioral phenotypes (wing buzzing, rolling and wings up posture) and have altered patterns of locomotion, compared to controls; on a more complete diet, locomotion is similar to that of controls; recordings from the dorsal longitudinal muscle in these flies on a sugar-only, but not control, diet show increased firing, compared to controls, with high frequency burst discharges.

All sgll⁹⁵ homozygous flies die within 6 days when raised on a 4% sucrose-only diet, whereas no control flies die in this period. However, mutant flies survive well on 5% yeast, or 5% yeast plus 4% sucrose, and consume similar amounts of food as controls, demonstrating that the lethality is not caused by impaired feeding or sucrose toxicity.

In contrast to controls, all animals that are transheterozygous for sgll⁹⁵ and Df(3R)ED7665, Df(3R)ED5223, Df(3R)BSC513 or Df(3R)BSC729 die when raised on a 4% sucrose-only diet. The number of sgll⁹⁵/Df flies emerging from these crosses is also much fewer than expected, and these escapers do not survive well even on standard fly food.

Compared with 100% death by day 6 when sgll⁹⁵ homozygotes are raised on 4% sucrose-only food, raising mutants on food supplemented with dietary vitamin B6 (either pyridoxine or its active form, pyridoxal 5'-phosphate) supplement increases survival in a dose-dependent manner.

sgll⁹⁵ has short lived phenotype, suppressible by Scer\GAL4^Act5C.PI/Hsap\PNPO^UAS.cCa

sgll⁹⁵ has abnormal locomotor behavior | adult stage | nutrition conditional phenotype, suppressible by Scer\GAL4^Act5C.PI/Hsap\PNPO^UAS.cCa

sgll⁹⁵ has abnormal behavior | adult stage phenotype, suppressible by Scer\GAL4^Act5C.PI/Hsap\PNPO^UAS.cCa

sgll⁹⁵ has abnormal neurophysiology | adult stage | nutrition conditional phenotype, suppressible by Scer\GAL4^Act5C.PI/Hsap\PNPO^UAS.cCa