FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lncRNA:let7CUAS.cSa
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General Information
Symbol
Dmel\lncRNA:let7CUAS.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0297477
Feature type
allele
Associated gene
Dmel\lncRNA:let7C
Associated Insertion(s)
Carried in Construct
P{UAS-let7C}
Also Known As
UAS-let-7-C
Key Links
Transgenic product class
wild_type
(Wu et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wu et al., 2012)
Mutagen
in vitro construct
(Wu et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-let7C}
Cytology
Description

UAS regulatory sequences drive expression of the lncRNA:let7C polycistronic transcription unit which encodes the mir-100, let-7 and mir-125 microRNAs.

(Wu et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
lncRNA:let7C
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by ph-d505, ph-p505
      (Jiang et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing lncRNA:let7CUAS.cSa under the control of either Scer\GAL4Tub.Switch.PU or Scer\GAL4da.Switch.PT significantly increases the adult life span of females treated with RU486 (to switch on transgene expression) under a high-nutrient diet, compared to untreated and wild-type controls. On the contrary, expression under Scer\GAL4Tub.Switch.PU leads to a moderate (but significant) decrease in lifespan of males treated with RU486 compared to untreated controls. RU486-treated females fed a low-nutrient diet also display a significant increase in lifespan when expression is driven under the control of Scer\GAL4Tub.Switch.PU.

      Expressing lncRNA:let7CUAS.cSa under the control of Scer\GAL4Switch1.106, Scer\GAL4elav.Switch.PO or Scer\GAL4TIGS-2 nas no effect on the lifespan of females treated with RU486 (to switch on transgene expression) compared to untreated controls. Expression under the control of Scer\GAL4Tub.Switch.PU has no impact on fecundity in females treated with RU486.

      (Gendron and Pletcher, 2017)

      Scer\GAL4ey-OK107-mediated expresson of let-7-CScer\UAS.cSa results in dramatic effects on adult mushroom body morphology, including the apparent elimination of γ as well as α'/β' lobes.

      (Wu et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      let-7-CScer\UAS.cSa
      lncRNA:let7CScer\UAS.cSa
      lncRNA:let7CUAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)