FB2026_02 , released June 18, 2026
Allele: Dmel\Elp3Ex1
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General Information
Symbol
Dmel\Elp3Ex1
Species
D. melanogaster
Name
FlyBase ID
FBal0297900
Feature type
allele
Associated gene
Dmel\Elp3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele

Mutagen
Nature of the Allele
Allele class

amorphic allele

(Walker et al., 2011)
Mutagen
Delta2-3 transposase
(Walker et al., 2011)
Progenitor genotype
P{EP}morgueEP2367
(Walker et al., 2011)
Cytology
Description

Imprecise excision of P{EP}morgueEP2367 results in a deletion from 65bp upstream of the Elp3 transcription start site to the triplet encoding K277.

(Walker et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:4,444,667..4,445,756 [+]
Comment:

A deletion resulting from the imprecise excision of P{EP}morgueEP2367. The deletion is reported as extending from the insertion site to codon K277; (not clear if K277 is deleted or not; mapped deletion does not include K277).

(Walker et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Elp3Ex1 mutant larvae show a profound developmental delay and die during pupariation. Progression to the third instar larval stage is delayed and growth is slow. Growth of the larval leg discs and wing discs is severely impaired. Salivary glands remain small.

      Elp3Ex1 mutant larvae exhibit melanotic nodules. Lamellocyte numbers are unchanged but hemocyte numbers are reduced, and the remaining hemocytes aggregate to form micronodules, which are in circulation. Crystal cell number are also unchanged.

      (Walker et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Elp3Ex1 is partially rescued by Scer\GAL4Act5C.PI/Elp3UAS.Tag:HA

      (Walker et al., 2011)
      Comments

      Ubiquitous expression of Elp3Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act5C.PI rescues the lethality associated with Elp3Ex1. However, while the resulting males show normal fertility, the females are sterile.

      (Walker et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The expression of morgue is unaffected in Elp3Ex1.

      (Walker et al., 2011)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Elp3Ex1
      (Walker et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)