FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LaspΔSH3.L.UAS.Tag:FLAG,Tag:polyHis
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General Information
Symbol
Dmel\LaspΔSH3.L.UAS.Tag:FLAG,Tag:polyHis
Species
D. melanogaster
Name
FlyBase ID
FBal0298078
Feature type
allele
Associated gene
Dmel\Lasp
Associated Insertion(s)
Carried in Construct
P{UAS-Lasp.L.ΔSH3}
Key Links
Transgenic product class
inframe_deletion
(Fernandes and Schöck, 2014)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Fernandes and Schöck, 2014)
Mutagen
in vitro construct
(Fernandes and Schöck, 2014)
Progenitor genotype
Carried in construct
P{UAS-Lasp.L.ΔSH3}
Cytology
Description

UASt regulates expression of amino acids 1-657, corresponding to Lasp-PB, but with the SH3 domain deleted (a stop at D507), and tagged at the N-terminus with Tag:FLAG and Tag:polyHis.

(Fernandes and Schöck, 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Lasp
Tagged with
Tag:FLAG
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4Mef2.PR/LaspΔSH3.L.UAS.Tag:FLAG,Tag:polyHis fails to rescue Lasp1

      (Fernandes and Schöck, 2014)
      Comments

      Scer\GAL4Mef2.PR-mediated expression of LaspΔSH3.L.Scer\UAS.T:Zzzz\FLAG,T:Zzzz\His6 cannot rescue the sarcomere length, thin filament length, myofibril diameter or flight phenotypes seen in Lasp1 mutants.

      (Fernandes and Schöck, 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LaspΔSH3.L.Scer\UAS.T:Zzzz\FLAG,T:Zzzz\His6
      LaspΔSH3.L.UAS.Tag:FLAG,Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (1)