FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LaspY121S.L.UAS.Tag:FLAG,Tag:polyHis
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General Information
Symbol
Dmel\LaspY121S.L.UAS.Tag:FLAG,Tag:polyHis
Species
D. melanogaster
Name
FlyBase ID
FBal0298080
Feature type
allele
Associated gene
Dmel\Lasp
Associated Insertion(s)
Carried in Construct
P{UAS-Lasp.L.Y121S}
Key Links
Transgenic product class
missense_variant
(Fernandes and Schöck, 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Fernandes and Schöck, 2014)
Mutagen
in vitro construct
(Fernandes and Schöck, 2014)
Progenitor genotype
Carried in construct
P{UAS-Lasp.L.Y121S}
Cytology
Description

UASt regulates expression of amino acids 1-657, corresponding to Lasp-PB, bearing a Y121S substitution in the actin-binding SDxxYK motif in nebulin repeat 2, and tagged at the N-terminus with Tag:FLAG and Tag:polyHis.

(Fernandes and Schöck, 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Lasp
Tagged with
Tag:FLAG
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      LaspY121S.L.UAS.Tag:FLAG,Tag:polyHis/Scer\GAL4Mef2.PR fails to rescue Lasp1

      (Fernandes and Schöck, 2014)
      Comments

      Scer\GAL4Mef2.PR-mediated expression of LaspY121S.L.Scer\UAS.T:Zzzz\FLAG,T:Zzzz\His6 cannot rescue the sarcomere length, thin filament length, myofibril diameter or flight phenotypes seen in Lasp1 mutants. EM analyses reveal that filament number, but not filament spacing, is partially rescued.

      (Fernandes and Schöck, 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LaspY121S.L.Scer\UAS.T:Zzzz\FLAG,T:Zzzz\His6
      LaspY121S.L.UAS.Tag:FLAG,Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (1)