FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\slmbunspecified
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General Information
Symbol
Dmel\slmbunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0298291
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    In females with slmbunspecified germline clones 17.4% of follicles exhibit abnormalities: i. 3.7% exhibit features of apoptosis, such as germ cell nuclear fragmentation ii. 9.9% exhibit increased numbers of germ cells iii. 1.7% exhibit decreased numbers of germ cells iv. 2.9% have germ cell nuclei that are heterogeneous in size. In slmbunspecified germline clones, all oocytes from follicles with extra nurse cells and one single oocyte exhibit five ring canals instead of four, indicating that an extra round of mitosis has occurred. All observed egg chambers with two oocytes exhibit four ring canals per oocyte. Egg chambers with somatic slmbunspecified follicle cell clones also display a range of defects. Such egg chambers frequently contain two oocytes and extra nurse cells within a single follicular epithelium. Ovarioles often exhibit germaria in which two or more cysts are placed side by side in regions IIb and III. The egg chambers are frequently an aberrant shape and have mispositioned oocytes within the follicle, adopting an anterior or lateral location. Finally, some ovarioles lack interfollicular stalks between adjacent follicles and are instead separated by a layer of epithelial cells. Eggs laid by females in which slmbunspecified germline clones induced by heat shock exhibit diverse patterning defects. These eggs are often smaller than wild-type eggs and are abnormal in shape. Egg chambers with slmbunspecified somatic clones generate eggshells with variable dorsal appendage phenotypes. Some eggshells have a dorsalized phenotype, characterized by laterally expanded dorsal appendages, or in more severe cases, by dorsal appendages that surround the entire circumference of the egg. Other eggshells are apparently ventralized with dorsal appendages that are partially or totally fused. Some dorsal appendages are ramified. Additionally, eggshells exhibit a slightly enlarged operculum or a greatly reduced amount or absence of dorsal appendage material.

    Follicle cells are disorganised and migrate between the oocyte and the nurse cells in females containing homozygous germline clones. The oocyte is smaller than normal.

    Heterozygotes have necrotic areas on the wings.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    slmbunspecified fuunspecified transheterozygotes show duplication of anterior adult structures (legs, wings and thorax).

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    slmbunspecified
    welunspecified
    Name Synonyms
    Secondary FlyBase IDs
    • FBal0085814
    • FBal0151339
    References (6)