FlyBase Allele Report: Dmel\Sod2[UAS.cUa]

General Information

Symbol

Dmel\Sod2^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0298311

Feature type

allele

Associated gene

Dmel\Sod2

Associated Insertion(s)

Carried in Construct

P{UAS-Sod2.U}

Also Known As

UAS-Sod2

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Sod2.U}

Cytology

Description

UAS regulates expression of Sod2.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Sod2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Koh et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived, with Scer\GAL4^da.PU

(Gururaja Rao et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Sod2^UAS.cUa is a suppressor of short lived phenotype of slo¹

(Gururaja Rao et al., 2019)

Sod2^UAS.cUa, Scer\GAL4^ey.PU is a suppressor | partially of neoplasia | larval stage phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Scer\GAL4^Act5C.PI/Sod2^UAS.cUa is a suppressor | partially of abnormal oxidative stress response phenotype of Sdhaf3^null

(Na et al., 2014)

Sod2^UAS.cUa/Scer\GAL4^hs.PU is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Koh et al., 2012)

Scer\GAL4^ple.PF/Sod2^UAS.cUa is a suppressor of decreased cell number | adult stage phenotype of Pink1^B9

(Koh et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Sod2^UAS.cUa, Scer\GAL4^ey.PU is a suppressor | partially of eye disc phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Sod2^UAS.cUa/Scer\GAL4^hs.PU is a suppressor | partially of adult thorax phenotype of Pink1^B9

(Koh et al., 2012)

Sod2^UAS.cUa/Scer\GAL4^hs.PU is a suppressor | partially of mitochondrion | adult stage phenotype of Pink1^B9

(Koh et al., 2012)

Sod2^UAS.cUa/Scer\GAL4^hs.PU is a suppressor | partially of indirect flight muscle cell phenotype of Pink1^B9

(Koh et al., 2012)

Sod2^UAS.cUa/Scer\GAL4^hs.PU is a suppressor | partially of wing blade phenotype of Pink1^B9

(Koh et al., 2012)

Scer\GAL4^ple.PF/Sod2^UAS.cUa is a suppressor of dorso-lateral dopaminergic neuron phenotype of Pink1^B9

(Koh et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Sod2^Scer\UAS.cUa or Thor^Scer\UAS.cMa driven by Scer\GAL4^hs.PU partially suppresses phenotypes (collapsed thorax, downturned wings, reduced levels of mtDNA and ATP in the indirect flight muscle, and locomotor defects) seen in Pink1^B9/Y flies. Expression of Sod2^Scer\UAS.cUa or Thor^Scer\UAS.cMa driven by Scer\GAL4^ple.PF partially suppresses the enlarged mitochondria in dopaminergic neurons and dopaminergic neuron loss (DL1 cluster) seen in Pink1^B9/Y flies.

(Koh et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sod2^Scer\UAS.cUa

Sod2^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (9)

Report Sections

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