FB2026_03 , released September 17, 2026
Allele: Dmel\Fbxl7C616Y
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General Information
Symbol
Dmel\Fbxl7C616Y
Species
D. melanogaster
Name
FlyBase ID
FBal0298382
Feature type
allele
Associated gene
Dmel\Fbxl7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Bosch et al., 2014)
Mutagen
ethyl methanesulfonate
(Bosch et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: C616Y.

(Bosch et al., 2014)

C616Y change in a conserved residue in one of the leucine-rich repeats.

(Bosch et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,932,031..15,932,031 [+]
Nucleotide change:

G15932031A

Amino acid change:

C616Y | Fbxl7-PA

Reported amino acid change:

C616Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bosch et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant clones are over-represented in the eye compared to controls, demonstrating increased growth of the mutant tissue.

      The wings of Fbxl7C616Y homozygotes or hemizygotes are larger and more rounded than wild-type wings, and the distance between the cross veins is reduced.

      (Bosch et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fbxl7C616Y
      (Bosch et al., 2014)
      fbxl7C616Y
      (Zhang et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)