FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Usp5leon-2
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General Information
Symbol
Dmel\Usp5leon-2
Species
D. melanogaster
Name
FlyBase ID
FBal0298994
Feature type
allele
Associated gene
Dmel\Usp5
Associated Insertion(s)
Carried in Construct
Also Known As
leon2
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Wang et al., 2014)
Mutagen
ethyl methanesulfonate
(Wang et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: G225R.

(Wang et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:3,147,312..3,147,312 [-]
Nucleotide change:

G3147312M

Amino acid change:

G225R | Usp5-PA; G225R | Usp5-PB; G225R | Usp5-PC

Reported amino acid change:

G225R

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Wang et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Usp5leon-2/Usp519-2 mutant third instar larvae display neuromuscular junction defects, the synaptic boutons are aggregated and less numerous compared to wild-type controls. The muscle area is comparable to controls.

      (Wang et al., 2017)

      Usp5leon-2/Usp519-2 larval growth is slower compared to controls.

      (Wang et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Usp5leon-2 is rescued by Usp5GFP

      (Wang et al., 2014)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Usp52
      Usp5leon-2
      leon2
      (Wang et al., 2017, Wang et al., 2014)
      usp5leon2
      (Komori et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)