FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NdufAF1ex80
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General Information
Symbol
Dmel\NdufAF1ex80
Species
D. melanogaster
Name
FlyBase ID
FBal0298999
Feature type
allele
Associated gene
Dmel\NdufAF1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Cho et al., 2012)
Mutagen
P-element activity
(Cho et al., 2012)
Progenitor genotype
NdufAF1EY09101
(Cho et al., 2012)
Cytology
Description

Imprecise excision of the CIA30EY09101 insertion, resulting in removal of the bulk of the P{EPgy2} element, leaving only a 517bp fragment that does not carry any identifiable genetic elements, but does contain start and stop codons in all three forward frames.

(Cho et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  mitochondrial metabolism disease
      CEA
      (Cho et al., 2012)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  mitochondrial metabolism disease
      is ameliorated by Scer\NDI1UAS.cBa
      (Cho et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant pupae are smaller than controls, but structurally similar. Rare escaper flies show severe degeneration of both myofibrils and mitochondria in thoracic flight muscles.

      (Cho et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      NdufAF1ex80 is rescued by Scer\GAL4da.PU/NdufAF1UAS.cCa

      (Cho et al., 2012)
      Comments

      Scer\GAL4da.PU-mediated expression of CIA30Scer\UAS.cCa rescues respiratory complex I assembly and the defective myofibrils and mitochondria of CIA30ex80 mutants.

      Scer\GAL4da.PU-mediated expression of CIA30Scer\UAS.cCa rescues the pupal lethality and small pupal size of CIA30ex80 mutants.

      (Cho et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CIA30ex80
      NdufAF1ex80
      dCIA30ex80
      (Cho et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)