Pan-neuronal expression of Uba1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^elav.PU results in decreased lifespan with minimal survival after 4 weeks.

Exposing flies expressing Uba1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^elav.PU to the pesticide maneb for 4 weeks results in significant loss of dopaminergic neurons compared to controls exposed to vehicle alone. No DA neuron loss is seen in controls. The magnitude of the loss is similar to that observed in wild type flies exposed to paraquat + maneb for four weeks. By contrast, no loss of DA neurons is seen when the flies are exposed to either paraquat alone or paraquat + maneb.