FlyBase Allele Report: Dmel\rols[HMJ22326]

General Information

Symbol

Dmel\rols^HMJ22326

Species

D. melanogaster

Name

FlyBase ID

FBal0300722

Feature type

allele

Associated gene

Dmel\rols

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ22326}

Also Known As

UAS-rols-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMJ22326}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ22326

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intellectual developmental disorder with autistic features and language delay, with or without seizures

CEC

(Guo et al., 2019)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior, with Scer\GAL4^repo

(Guo et al., 2019)

Phenotype Manifest In

NMJ bouton | increased number | third instar larval stage, with Scer\GAL4^C57

(Guo et al., 2019)

Detailed Description

Statement

Reference

The expression of rols^HMJ22326 under the control of Scer\GAL4^repo leads to significantly increased courtship-related wing extensions, but does not significantly affect courtship duration or success, grooming behavior or overall locomotion.

Expression under the control of either Scer\GAL4^repo or Scer\GAL4^nSyb.PU does not induce significant climbing defects or bang sensitivity.

Expression under the control of Scer\GAL4^elav.PU does not affect the frequency of courtship-related wing extensions.

Expression under the control of Scer\GAL4^C57 leads to third instar larval neuromuscular junctions showing significantly more satellite boutons, as compared to controls.

(Guo et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions