FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Trap1Δ4
Open Close
General Information
Symbol
Dmel\Trap1Δ4
Species
D. melanogaster
Name
FlyBase ID
FBal0300854
Feature type
allele
Associated gene
Dmel\Trap1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Treisman, 2014.11.20)
Mutagen
P-element activity
(Treisman, 2014.11.20)
Progenitor genotype
P{EPgy2}Trap1EY10238
(Treisman, 2014.11.20)
Cytology
Description

A full-length deletion of the Trap1 locus resulting from imprecise excision of the P-element.

(Baqri et al., 2014)

Imprecise excision of the P{EPgy2}Trap1EY10238 progenitor insertion, which removes the entire Trap1 coding sequence and part of the 5' UTR.

(Treisman, 2014.11.20)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:6,633,810..6,636,226 [-]
Comment:

2417 bp deletion, resulting from the imprecise excision of the P{EPgy2}Trap1EY10238 progenitor insertion, which removes the indicated sequences, encompassing the entire Trap1 coding sequence and part of the 5' UTR.

(Treisman, 2014.11.20)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      5 day old mutant brains show increased reactive oxygen species. Mitochondrial distribution is not significantly altered.

      Young mutant males, but not females, are significantly more susceptible to oxidative stress (paraquat exposure) compared to controls.

      In both male and female mutants, survival after heat shock applied at 19 days of age is significantly decreased compared to controls.

      The lifespan of male and female mutants is not significantly different from controls.

      Locomotor performance in mutant flies is moderately decreased at older age compared to controls.

      Mutant females show severely compromised fecundity at all age-points, and mutant males appear to be less fertile than controls.

      (Baqri et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Trap1Δ4 is rescued by Scer\GAL4Act.PU/Trap1UAS.cBa

      (Baqri et al., 2014)
      Comments

      Scer\GAL4Act.PU-mediated expression of Trap1Scer\UAS.cBa rescues survival of Trap1Δ4 male flies exposed to paraquat.

      (Baqri et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      TRAPΔ4
      (Baqri et al., 2014)
      Trap1Delta4
      (Treisman, 2014.11.20)
      Trap1Δ4
      Trap1Δ4
      (Kokott-Vuong et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)