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General Information
Symbol
Dmel\p53UAS.cUa
Species
D. melanogaster
Name
UAS construct of Unknown
FlyBase ID
FBal0300953
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-p53
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulates expression of p53.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Cardiac-specific (Scer\GAL4tin.CΔ4) overexpression of p53Scer\UAS.cUa causes significant slowing of heart period and structural cardiac defects (similar to those seen in Scer\GAL4tin.CΔ4>ScoxGD898 flies).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Flies with co-expression of p53Scer\UAS.cUa along with Scer\GAL4tin.CΔ4>ScoxGD898 have no heartbeat and show significant heart degeneration, with complete loss of cardiac myofibrils.

Co-expression of Surf1KK108032 suppresses the myofibrillar disorganization seen in hearts of Scer\GAL4tin.CΔ4>p53Scer\UAS.cUa flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
p53Scer\UAS.cUa
p53UAS.cUa
Name Synonyms
UAS construct of Unknown
Secondary FlyBase IDs
    References (6)