FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PenS56A.UASp.cGa
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General Information
Symbol
Dmel\PenS56A.UASp.cGa
Species
D. melanogaster
Name
FlyBase ID
FBal0300960
Feature type
allele
Associated gene
Dmel\Pen
Associated Insertion(s)
Carried in Construct
P{UASp-Pen.S56A.G}
Key Links
Transgenic product class
missense_variant
(Gorjanacz et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Gorjanacz et al., 2006)
Mutagen
in vitro construct
(Gorjanacz et al., 2006)
Progenitor genotype
Carried in construct
P{UASp-Pen.S56A.G}
Cytology
Description

UASp regulatory sequences drive expression of mutated Pen cDNA sequence, which contains the amino acid replacement S56A.

(Gorjanacz et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Pen
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4VP16.nanos.UTR/PenS56A.UASp.cGa partially rescues PenD14

      (Gorjanacz et al., 2006)
      Fails to rescue

      Scer\GAL4c747/PenS56A.UASp.cGa fails to rescue PenmbmB

      (Serway et al., 2020)
      Comments

      Expression of PenS56A.Scer\UAS.P\T.cGa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in PenD14 females restores egg laying to an average of 12.4 eggs/day. Meiosis occurs in most eggs, with the formation of polar bodies. However, mitosis in the embryos is considerably delayed and asynchronous. Only 3.4% of the eggs hatch.

      (Gorjanacz et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PenS56A.Scer\UAS.P\T.cGa
      PenS56A.UASp.cGa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)