FlyBase Allele Report: Dmel\S6k[HMS04459]

General Information

Symbol

Dmel\S6k^HMS04459

Species

D. melanogaster

Name

FlyBase ID

FBal0301019

Feature type

allele

Associated gene

Dmel\S6k

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS04459}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS04459}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS04459

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

(Sopko et al., 2014)

Phenotype Manifest In

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Sopko et al., 2014)

female germline stem cell | decreased number, with Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

Detailed Description

Statement

Reference

Females heterozygous for S6k^HMS04459 and Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} crossed to S6k^HMS04459 males results in: 27% hatching; egg/embryonic phenotype: "variable U-shaped, segmentation defects and fusion"; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

S6k^HMS04459, Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of decreased cell number | oogenesis phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

Phenotype Manifest In

Suppressor of

Statement

Reference

S6k^HMS04459, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female fusome phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

S6k^HMS04459, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female germline cyst phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

S6k^HMS04459, Scer\GAL4^{VP16.nanos.UTR} is a suppressor | partially of oocyte phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

NOT Suppressor of

Statement

Reference

S6k^HMS04459, Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of female germline stem cell | decreased number phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

57016

y¹ sc^* v¹ sev²¹; P{TRiP.HMS04459}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

S6k^HMS04459

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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