FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MAPTUAS.2N4R.cAa
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General Information
Symbol
Hsap\MAPTUAS.2N4R.cAa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Appocher
FlyBase ID
FBal0301165
Feature type
allele
Associated gene
Hsap\MAPT
Associated Insertion(s)
Carried in Construct
P{UAS-Tau.2N4R.A}
Key Links
Transgenic product class
cDNA
(Appocher et al., 2014)
wild_type
(Appocher et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Appocher et al., 2014)
wild_type
(Appocher et al., 2014)
Mutagen
in vitro construct
(Appocher et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Tau.2N4R.A}
Cytology
Description

UAS regulatory sequences drive expression of a cDNA corresponding to the 2N4R isoform of Hsap\MAPT.

(Appocher et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\MAPT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  tauopathy
      CEC
      (Appocher et al., 2014)
      CEC with ReepAΔ258
      (Appocher et al., 2014)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  tauopathy
      is exacerbated by ReepAΔ258
      (Appocher et al., 2014)
      is exacerbated by ReepAΔ275
      (Appocher et al., 2014)
      is exacerbated by ReepAGD2168
      (Appocher et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Scer\GAL4GMR.PU>Hsap\MAPTScer\UAS.2N4R.cAa results in the abnormal formation of actin-rich structures within amyloid aggregates.

      (Appocher et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Scer\GAL4GMR.PU>Reep1GD2168 strongly enhances the neurodegeneration induced by Hsap\MAPTScer\UAS.2N4R.cAa expression. As a result of the enhanced neurotoxic effects, the surface area of the eye is further reduced and becomes more disorganised.

      Reep1Δ258/Reep1Δ275 enhances the neurodegeneration in retinas resulting from the expression of Scer\GAL4GMR.PU>Hsap\MAPTScer\UAS.2N4R.cAa resulting in the formation of extensive necrotic areas, visible as black spots, over the eye surface.

      Overexpression of Reep1Scer\UAS.T:Zzzz\FLAG ameliorates the Scer\GAL4GMR.PU>Hsap\MAPTScer\UAS.2N4R.cAa-induced eye-degeneration in the Reep1Δ258/Reep1Δ275 genetic background.

      Overexpression of Hsap\REEP1Scer\UAS.T:Zzzz\FLAG ameliorates the Scer\GAL4GMR.PU>Hsap\MAPTScer\UAS.2N4R.cAa-induced eye-degeneration in the Reep1Δ258/Reep1Δ275 genetic background.

      Reep1Δ258/Reep1Δ275 strongly increases the pathological formation of amyloid aggregates in retinas expressing Scer\GAL4GMR.PU>Hsap\MAPTScer\UAS.2N4R.cAa as well as the incidence of ectopic actin-rich structures within these amyloid clusters.

      (Appocher et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\MAPTScer\UAS.2N4R.cAa
      Hsap\MAPTUAS.2N4R.cAa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Appocher
      Secondary FlyBase IDs
        References (2)