FB2026_03 , released September 17, 2026
Allele: Dmel\IP3K2Δ1
Open Close
General Information
Symbol
Dmel\IP3K2Δ1
Species
D. melanogaster
Name
FlyBase ID
FBal0301386
Feature type
allele
Associated gene
Dmel\IP3K2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Nelson et al., 2014)
Progenitor genotype
PBac{RB}IP3K2e02492
(Nelson et al., 2014)
P{RS3}CB-0529-3
(Nelson et al., 2014)
Cytology
Description

FLP-mediated recombination between the two progenitor insertions has resulted in the deletion of most of IP3K2, including the conserved inositol polyphosphate kinase domain.

(Nelson et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:13,319,280..13,329,820 [+]
Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in a 10,540bp deletion of the genomic sequence between them, taking out most of IP3K2. The deletion was reported to map to X:13 ,213,313..13,223,853 (release 5 coordinates) while leaving a 2,241 base pair hybrid PBac{RB}/P{RS3} element.

(Nelson et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      IP3K2Δ1/IP3K2Δ1 is a suppressor of salivary gland | pupal stage phenotype of mir-14Δ1

      (Nelson et al., 2014)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduction in salivary gland autophagy and persistent salivary gland phenotype which is seen in mir-14Δ1 homozygous pupae is suppressed in IP3K2Δ1/Y ; mir-14Δ1/mir-14Δ1 double mutant pupae.

      The reduction of autophagy which is seen in the salivary glands 14 hours after pupariation in animals expressing Itp-r83AKK100626 under the control of Scer\GAL4fkh.PU is still seen if the animals are also mutant for IP3K2Δ1.

      The reduction in salivary gland autophagy and persistent salivary gland phenotype which is seen in pupae expressing CamHMS01318 under the control of Scer\GAL4fkh.PU is still seen if the animals are also mutant for IP3K2Δ1.

      (Nelson et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference

      The inhibition of autophagy which is seen in the salivary glands 14 hours after pupariation in animals expressing Mmus\Itpr1IP3-sponge.m49.Scer\UAS under the control of Scer\GAL4fkh.PU is still seen if the animals are also mutant for IP3K2Δ1.

      (Nelson et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      IP3K2Δ1
      ip3k2Δ1
      (Nelson et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)