FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dwil\GK18382+ta
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General Information
Symbol
Dwil\GK18382+ta
Species
D. willistoni
Name
FlyBase ID
FBal0301415
Feature type
allele
Associated gene
Dwil\GK18382
Associated Insertion(s)
Carried in Construct
P{Dwil\GK18382.g}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Niepielko and Yakoby, 2014)
Progenitor genotype
Carried in construct
P{Dwil\GK18382.g}
Cytology
Description

The Dwil\GK18382 genomic locus is cloned into a modified pBw plasmid (with the Scer\GAL4, terminator and promoter regions removed) and inserted at position 68A4 in Drosophila melanogaster flies using attP2.

(Niepielko and Yakoby, 2014)
Allele components
Component
Use(s)
Regulatory region(s)
Dwil\GK18382
Encoded product / tool
Dwil\GK18382
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The addition of two copies of Dwil\GK18382+ta to wild-type D. melanogaster flies results in a wider gap between the dorsal appendages. There is also a clear increase in the area posterior to the base of the dorsal appendages.

      (Niepielko and Yakoby, 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The presence of one or two copies of Dwil\GK18382+ta in grk2B6/grk2E12 mutant D. melanogaster flies results in four distinct eggshell phenotypes. Most eggshells, 69% and 78% from one and two copies of Dwil\GK18382+ta, respectively, are wild-type or wild-type with an enlarger area posterior to the base of the dorsal appendages, similar to wild-type flies expressing Dwil\GK18382+ta. A dorsal ridge-like morphology is found in 10% and 1% of the eggshells from one and two copies of Dwil\GK18382+ta, respectively.

      In 13% and 18% of the eggshells from in grk2B6/grk2E12 mutant D. melanogaster with one and two copies of Dwil\GK18382+ta, respectively, there is a single or fused dorsal appendage.

      In 8% and 3% of the eggshells from in grk2B6/grk2E12 mutant D. melanogaster with one and two copies of Dwil\GK18382+ta, respectively, the eggshells are collapsed and the eggs unmountable.

      (Niepielko and Yakoby, 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dwil\GK18382+ta
      Name Synonyms
      Secondary FlyBase IDs
        References (1)