FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sema2aunspecified
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General Information
Symbol
Dmel\Sema2aunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0301594
Feature type
allele
Associated gene
Dmel\Sema2a
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Sema-2aunspecified mutant germline clones show oocyte mislocalisation. Oogenesis arrests at stage 4-6.

        (Kucherenko et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        Sema-2a[+]/Sema2aunspecified is an enhancer of visible phenotype of DgRNAi.UAS, Scer\GAL4Tub.PU

        (Kucherenko et al., 2008)
        Suppressor of
        Statement
        Reference

        Sema-2a[+]/Sema2aunspecified is a suppressor of visible phenotype of DysRNAi.NH2.UAS, Scer\GAL4Act.PU

        (Kucherenko et al., 2008)

        Sema-2a[+]/Sema2aunspecified is a suppressor of visible phenotype of DysRNAi.C.UAS, Scer\GAL4Tub.PU

        (Kucherenko et al., 2008)
        Other
        Statement
        Reference

        DysE6, Sema-2a[+]/Sema2aunspecified has visible phenotype

        (Kucherenko et al., 2008)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        Sema-2a[+]/Sema2aunspecified is an enhancer of posterior crossvein phenotype of DgRNAi.UAS, Scer\GAL4Tub.PU

        (Kucherenko et al., 2008)
        Suppressor of
        Statement
        Reference

        Sema-2a[+]/Sema2aunspecified is a suppressor of posterior crossvein phenotype of DysRNAi.NH2.UAS, Scer\GAL4Act.PU

        (Kucherenko et al., 2008)

        Sema-2a[+]/Sema2aunspecified is a suppressor of posterior crossvein phenotype of DysRNAi.C.UAS, Scer\GAL4Tub.PU

        (Kucherenko et al., 2008)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        One copy of Sema-2aunspecified weakly suppresses the detached posterior crossvein phenotype seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

        One copy of Sema-2aunspecified weakly suppresses the detached posterior crossvein phenotype seen when DysdsRNA.C.Scer\UAS is expressed under the control of Scer\GAL4tub.PU but produces extra wing vein material.

        One copy of Sema-2aunspecified in a DysE6/+ background results in posterior crossvein defects.

        One copy of Sema-2aunspecified enhances the posterior crossvein phenotype seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

        (Kucherenko et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Sema-2aunspecified
        Sema2aunspecified
        sema-2ak13416
        (Kucherenko et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)