FlyBase Allele Report: Dmel\Nav[UAS.cAa]

General Information

Symbol

Dmel\Nav^UAS.cAa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Abe

FlyBase ID

FBal0301623

Feature type

allele

Associated gene

Dmel\Nav

Associated Insertion(s)

Carried in Construct

P{UAS-Nav.A}

Key Links

Transgenic product class

wild_type

(Abe et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Abe et al., 2014)

Mutagen

in vitro construct

(Abe et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-Nav.A}

Cytology

Description

UAS regulatory sequences drive expression of sick.

(Abe et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Nav

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Nav^A384/Nav^Δ, Scer\GAL4^elav.PU

(Abe et al., 2014)

abnormal neuroanatomy, with Scer\GAL4^elav.PU

(Abe et al., 2014)

Phenotype Manifest In

adult mushroom body beta-lobe, with Nav^A384/Nav^Δ, Scer\GAL4^elav.PU

(Abe et al., 2014)

adult mushroom body beta-lobe, with Scer\GAL4^elav.PU

(Abe et al., 2014)

Detailed Description

Statement

Reference

The mushroom bodies of flies expressing sick^Scer\UAS.cAa under the control of Scer\GAL4^elav.PU display β-lobe fusion.

(Abe et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^elav.PU/Nav^UAS.cAa partially rescues Nav^A384/Nav^Δ

(Abe et al., 2014)

Scer\GAL4^ey-OK107/Nav^UAS.cAa partially rescues Nav^A384/Nav^Δ

(Abe et al., 2014)

Scer\GAL4^NP7175/Nav^UAS.cAa partially rescues Nav^A384/Nav^Δ

(Abe et al., 2014)

Comments

Expression of sick^Scer\UAS.cAa under the control of Scer\GAL4^elav.PU almost fully rescues the axonal growth defects seen in the α/β mushroom body lobes of sick^Δ/sick^A384 mutants. The rescued flies exhibit a β lobe fusion phenotype.

Expression of sick^Scer\UAS.cAa under the control of Scer\GAL4^ey-OK107 significantly rescues the axonal growth defects seen in the α/β mushroom body lobes of sick^Δ/sick^A384 mutants.

Expression of sick^Scer\UAS.cAa under the control of Scer\GAL4^NP7175 significantly rescues the axonal growth defects seen in the α/β mushroom body lobes of sick^Δ/sick^A384 mutants.

(Abe et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Nav^UAS.cAa

sick^Scer\UAS.cAa

sick^UAS.cAa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Abe

Secondary FlyBase IDs

References (2)

Report Sections

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