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General Information
Symbol
Dmel\sickUAS.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0301624
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of sick tagged at the N-terminal end with mCherry.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of sickScer\UAS.T:Disc\RFP-mCherry suppresses the medial axon growth defect and F-actin elevation seen in the α/β mushroom body lobes when LIMK1Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4ey-OK107. Dorsal axon defects are still observed.

The axon growth and increased F-actin phenotypes seen in α/β lobe mushroom body clones expressing LIMK1Scer\UAS.T:Ivir\HA1 are suppressed by sickScer\UAS.T:Disc\RFP-mCherry. ssh1-63 reverses this suppression, with LIMK1Scer\UAS.T:Ivir\HA1 sickScer\UAS.T:Disc\RFP-mCherry ssh1-63 triple mutant clones showing the more severe highly elevated F-actin and 'posterior arrest' (failure of axons to extend to form peduncles and lobe structures) phenotypes seen in LIMK1Scer\UAS.T:Ivir\HA1, ssh1-63 mutants. The phenotype seen in LIMK1Scer\UAS.T:Ivir\HA1, ssh1-63 double mutant clones is more severe than in either single mutant.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of sickScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4elav.PU almost fully rescues the axonal growth defects seen in the α/β mushroom body lobes of sickΔ/sickA384 mutants.

Expression of sickScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4ey-OK107 significantly rescues the axonal growth defects seen in the α/β mushroom body lobes of sickΔ/sickA384 mutants.

Expression of sickScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4NP7175 significantly rescues the axonal growth defects seen in the α/β mushroom body lobes of sickΔ/sickA384 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
sickScer\UAS.T:Disc\RFP-mCherry
sickUAS.mCherry
Name Synonyms
Secondary FlyBase IDs
    References (1)