Expression of sickScer\UAS.T:Disc\RFP-mCherry suppresses the medial axon growth defect and F-actin elevation seen in the α/β mushroom body lobes when LIMK1Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4ey-OK107. Dorsal axon defects are still observed.
The axon growth and increased F-actin phenotypes seen in α/β lobe mushroom body clones expressing LIMK1Scer\UAS.T:Ivir\HA1 are suppressed by sickScer\UAS.T:Disc\RFP-mCherry. ssh1-63 reverses this suppression, with LIMK1Scer\UAS.T:Ivir\HA1 sickScer\UAS.T:Disc\RFP-mCherry ssh1-63 triple mutant clones showing the more severe highly elevated F-actin and 'posterior arrest' (failure of axons to extend to form peduncles and lobe structures) phenotypes seen in LIMK1Scer\UAS.T:Ivir\HA1, ssh1-63 mutants. The phenotype seen in LIMK1Scer\UAS.T:Ivir\HA1, ssh1-63 double mutant clones is more severe than in either single mutant.