FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bgcn20093
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General Information
Symbol
Dmel\bgcn20093
Species
D. melanogaster
Name
FlyBase ID
FBal0301687
Feature type
allele
Associated gene
Dmel\bgcn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: ?12term.

    (Jin et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:23,858,666..23,858,666 [-]
    Nucleotide change:

    C23858666T

    Amino acid change:

    Q12term | bgcn-PA; Q12term | bgcn-PB

    Reported amino acid change:

    ?12term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Mutation reported as a premature stop codon after residue 12.

    (Jin et al., 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant germaria are tumorous, containing only undifferentiated germline stem cell-like single germ cells.

        bgcn20093 germline stem cell (GSC) clones outcompete normal, wild type GSCs and occupy their niches within germaria. This appears to happen by the mutant GSCs simply forcing out the neighbouring wild type GSCs, as neither apoptosis nor differentiation is induced.

        bgcn20093 germline stem cells (GSCs) divide at a similar rate to controls.

        (Jin et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        bgcn[+]/bgcn20093 is an enhancer of increased cell number | recessive phenotype of tut4

        (Chen et al., 2014)
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        bgcn20093 has female germline stem cell | germline clone phenotype, suppressible by shgR69

        (Jin et al., 2008)
        Enhancer of
        Statement
        Reference

        bgcn[+]/bgcn20093 is an enhancer of testis phenotype of tut4

        (Chen et al., 2014)

        bgcn[+]/bgcn20093 is an enhancer of spermatogonium phenotype of tut4

        (Chen et al., 2014)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Introducing bgcn20093/+ or bgcnQS2/+ into the tut4 background results in the majority of germ cells continuing to divide but unable to differentiate beyond spermatogonial stage.

        (Chen et al., 2014)

        Unlike bgcn20093 germline stem cell (GSC) clones, clones carrying both bgcn20093 and shgR69 do not outcompete wild type GSCs.

        (Jin et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        bgcn20093
        (Shan et al., 2017, Chen et al., 2014, Jin et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)