FlyBase Allele Report: Dmel\mir-990[KO]

General Information

Symbol

Dmel\mir-990^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0301950

Feature type

allele

Associated gene

Dmel\mir-990

Associated Insertion(s)

TI{TI}mir-990^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2014)

Mutagen

ends-out gene targeting

(Chen et al., 2014)

FLPase

(Chen et al., 2014)

I-SceI

(Chen et al., 2014)

cre recombinase

(Chen et al., 2014)

Progenitor genotype

Associated Insertion(s)

TI{TI}mir-990^KO

Cytology

Description

The mir-990 hairpin has been deleted. A single loxP site is present at the site of the deletion. It is not known whether or not expression of the host CG8910 gene is affected.

(Chen et al., 2014)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile

(Chen et al., 2014)

long lived | male (with Df(2R)BSC382)

(Chen et al., 2014)

male fertile

(Chen et al., 2014)

short lived | female | recessive

(Chen et al., 2014)

short lived | male | recessive

(Chen et al., 2014)

some die during embryonic stage (with Df(2R)BSC382)

(Chen et al., 2014)

some die during embryonic stage | recessive

(Chen et al., 2014)

Phenotype Manifest In

germline cell | embryonic stage | maternal effect (with Df(2R)BSC382)

(Chen et al., 2014)

Detailed Description

Statement

Reference

Embryos derived from mir-990^KO/Df(2R)BSC382 embryos show a significant decrease in the number of primordial germ cells compared to embryos from control females.

Homozygous males and females show a significant decrease in median lifespan compared to controls.

mir-990/Df(2R)BSC382 males show a significant increase in median lifespan compared to controls.

(Chen et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

miR-990 KO

(Li et al., 2021)

mir-990^KO

(Niu et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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