FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ScrΔDYTQL.CTD.UAS
Open Close
General Information
Symbol
Dmel\ScrΔDYTQL.CTD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0301971
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
P{UAS-Scr.ΔDYTQL.CTD}
Key Links
Transgenic product class
inframe_deletion
(Percival-Smith et al., 2013)
missense_variant
(Percival-Smith et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Percival-Smith et al., 2013)
missense_variant
(Percival-Smith et al., 2013)
Mutagen
in vitro construct
(Percival-Smith et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Scr.ΔDYTQL.CTD}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of Scr lacking the DYTQL motif (a D111Q substitution and deletion of amino acids 112-118) and CTD domain (deletion of amino acids 388-390).

(Percival-Smith et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Scr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ScrΔDYTQL.CTD.Scer\UAS under the control of Scer\GAL4arm.PU results in ectopic T1 beards. Ectopic tarsi are seen when ScrΔDYTQL.CTD.Scer\UAS is expressed under the control of Scer\GAL4dpp.PU.

      The antennae of flies expressing ScrΔDYTQL.CTD.Scer\UAS under the control of Scer\GAL4pb.PJ are not wild type but do not exhibit an obvious transformation to proboscis identity. Patches of tricombless, convoluted cuticle are seen at higher temperatures.

      (Percival-Smith et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of ScrΔDYTQL.CTD.Scer\UAS and pbScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pb.PJ results in a strong transformation of the antenna to proboscis. This phenotype is seen at room temperature or 28.5[o]C. Tricombless cuticle is also seen in the maxillary palp. No evidence of a labial cap and chemosensory bristles is observed in theses patches of tricombless cuticle.

      Expression of ScrΔDYTQL.CTD.Scer\UAS under the control of Scer\GAL4pb.PJ in a pb27/pb20 mutant background results in an antenna to proboscis transformation: deformed antennae with patches of tricombless, convoluted cuticle are seen. Tricombless cuticle is also seen in the pb27/pb20 mutant vestigial maxillary palp. No evidence of a labial cap and chemosensory bristles is observed in theses patches of tricombless cuticle.

      (Percival-Smith et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ScrΔDYTQL.CTD.Scer\UAS
      ScrΔDYTQL.CTD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)