FB2026_02 , released June 18, 2026
Allele: Dmel\Toll-65A
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General Information
Symbol
Dmel\Toll-65A
Species
D. melanogaster
Name
FlyBase ID
FBal0302472
Feature type
allele
Associated gene
Dmel\Toll-6
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
TALEN
(Paré et al., 2014)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Toll-65A mutant embryos do not display defects in cell intercalation.

      (Paré et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Toll-65A, Tollo59 has embryo | maternal effect phenotype, suppressible by 18wKI.WT

      (Tamada et al., 2021)
      NOT suppressed by
      Statement
      Reference

      Toll-65A, Tollo59 has embryo | maternal effect phenotype, non-suppressible by 18wC2YF

      (Tamada et al., 2021)
      Other
      Statement
      Reference

      18wattP, Toll-65A, Tollo59 has embryo | maternal effect phenotype

      (Tamada et al., 2021)

      18wΔ76, Toll-6[+]/Toll-65A, Tollo[+]/Tollo59 has embryo phenotype

      (Paré et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      18wΔ76/+; Tollo59/+; Toll-65A/+ triple mutants display a significant reduction in axis elongation.

      Cell intercalation is reduced by 17% in embryos defective for 18wΔ76 and Toll-65A.

      Cell intercalation is reduced by 19% in embryos defective for Tollo59 and Toll-65A.

      Cell intercalation is reduced by more than 30% in embryos defective for 18wΔ76; Tollo59; Toll-65A, accompanied by slower edge contraction.

      In more than one third of cell rearrangements in 18wΔ76; Tollo59; Toll-65A triple mutant embryos, new edges fail to form, are unstable, or form in the wrong direction.

      (Paré et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Toll-65A
      (Tamada et al., 2021, Paré et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)