FlyBase Allele Report: Dmel\subdued[Δ5265]

General Information

Symbol

Dmel\subdued^Δ5265

Species

D. melanogaster

Name

FlyBase ID

FBal0302718

Feature type

allele

Associated gene

Dmel\subdued

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Jang et al., 2015)

Mutagen

FLPase

(Jang et al., 2015)

Progenitor genotype

PBac{RB}subdued^e01958

(Jang et al., 2015)

PBac{RB}subdued^e02779

(Jang et al., 2015)

Cytology

Description

Scer\FRT-mediated recombination between the two progenitor insertions PBac{RB}subdued^e02779 and PBac{RB}subdued^e01958 has deleted the sequence between them, resulting in a 5265bp deletion that removes most of the exons (and all of the transmembrane domains) of subdued.

(Jang et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:19,635,431..19,640,696 [-]

Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Jang et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal pain response | adult stage (with Df(3R)Exel6184)

(Jang et al., 2015)

abnormal pain response | larval stage (with Df(3R)Exel6184)

(Jang et al., 2015)

abnormal pain response | larval stage | recessive

(Jang et al., 2015)

partially lethal

(Jang et al., 2015)

semi-sterile

(Jang et al., 2015)

some die during pupal stage

(Jang et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes show partial lethality at the pupal stage. Adult escapers are partially sterile, but are morphologically normal and have normal walking and flying behaviour.

subdued^Δ5265/Df(3R)Exel6184 larvae show a normal response to gentle touch.

Homozygous adults show normal geotactic climbing ability.

subdued^Δ5265/Df(3R)Exel6184 larvae and adults show an impaired nociceptive heat response.

(Jang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

TrpA1[+]/TrpA1¹, subdued^Δ5265 has abnormal pain response | dominant | larval stage phenotype

(Jang et al., 2015)

TrpA1[+]/TrpA1¹, subdued^Δ5265 has abnormal pain response | dominant | adult stage phenotype

(Jang et al., 2015)

pain^EP2451/pain[+], subdued^Δ5265 has abnormal pain response | dominant | larval stage phenotype

(Jang et al., 2015)

pain^EP2451/pain[+], subdued^Δ5265 has abnormal pain response | dominant | adult stage phenotype

(Jang et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

TrpA1¹ subdued^Δ5265 double heterozygous larvae and adults show an impaired nociceptive heat response.

pain^EP2451; subdued^Δ5265 double heterozygous larvae and adults show an impaired nociceptive heat response.

(Jang et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Df(3R)Exel6184/subdued^Δ5265 is rescued by Scer\GAL4^109(2)80/subdued^UAS.cJa

(Jang et al., 2015)

Comments

The impaired nociceptive heat response seen in subdued^Δ5265/Df(3R)Exel6184 larvae and adults is rescued by expression of subdued^Scer\UAS.cJa under the control of Scer\GAL4^109(2)80.

(Jang et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

subdued^Δ5265

(Jang et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close