FlyBase Gene Report: Dmel\subdued

General Information

Symbol

Dmel\subdued

Species

D. melanogaster

Name

subdued

Annotation Symbol

CG16718

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038721

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

subdued (subdued) encodes a chloride ion channel activated by calcium and heat belonging to the TMEM16 family. Its roles include host defense against ingested pathogenic bacteria and modulation of sensory neuronal signaling. [Date last reviewed: 2018-11-15] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

92A11-92A11

Sequence location

3R:19,633,418..19,642,722 [-]

Recombination map

3-66

RefSeq locus

NT_033777 REGION:19633418..19642722

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables calcium-activated cation channel activity

inferred from direct assay

(Le et al., 2019)

enables intracellularly calcium-gated chloride channel activity

inferred from direct assay

(Jang et al., 2015, Wong et al., 2013)

enables phospholipid scramblase activity

inferred from direct assay

(Le et al., 2019)

enables voltage-gated chloride channel activity

inferred from direct assay

(Wong et al., 2013)

NOT enables intracellularly calcium-gated chloride channel activity

inferred from direct assay

(Le et al., 2019)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables intracellularly calcium-gated chloride channel activity

traceable author statement

(Himmel et al., 2023)

enables phospholipid scramblase activity

inferred from biological aspect of ancestor with PANTHER:PTN001389043

(GO Reference Genome Project, 2011-)

enables protein dimerization activity

inferred from electronic annotation with InterPro:IPR032394

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in chloride transmembrane transport

inferred from direct assay

(Jang et al., 2015, Wong et al., 2013)

involved_in defense response to Gram-negative bacterium

inferred from mutant phenotype

(Wong et al., 2013)

involved_in detection of cold stimulus involved in thermoception

inferred from mutant phenotype

(Himmel et al., 2023)

involved_in detection of temperature stimulus involved in sensory perception of pain

inferred from mutant phenotype

(Himmel et al., 2023, Jang et al., 2015)

involved_in monoatomic cation transmembrane transport

inferred from direct assay

(Le et al., 2019)

involved_in plasma membrane phospholipid scrambling

inferred from direct assay

(Le et al., 2019)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in phospholipid translocation

inferred from biological aspect of ancestor with PANTHER:PTN001389043

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000267334

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ANOCTAMINS

UNCLASSIFIED VOLTAGE-GATED CHLORIDE CHANNEL SUBUNITS

PHOSPHOLIPID SCRAMBLASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ANOCTAMINS -: Anoctamins (or TMEM16 family members) are calcium-activated chloride channels (CaCC) with eight putative transmembrane domains. It is not clear whether all anoctamins possess CaCC activity. (Adapted from FBrf0223235 and PMID:25451786).
UNCLASSIFIED VOLTAGE-GATED CHLORIDE CHANNEL SUBUNITS -: This group comprises voltage-gated chloride channel subunits that do not classify under other groups in FlyBase.
PHOSPHOLIPID SCRAMBLASES -: Phospholipid scramblases mediate the transbilayer movement of phospholipids in an ATP-independent manner, disrupting plasma membrane asymmetry. (Adapted from FBrf0249228.)

Summary (Interactive Fly)

a calcium-activated chloride channel of the anoctamin family - moonlighting (multifunctional protein) protein - translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane - nonselective ion channel activity - expression in the renal tubule is implicated in bacterial immunity - expressed in the epithelial cells of the oviduct and in the spermathecal secretory cells that play a role in sperm storage and its release into the uterus - female sterility observed in mutant flies might be due to a failure to release either egg or sperm from the ovary or spermatica, respectively - functions in conjunction with the thermo-TRPs in thermal nociception

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\subdued for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4JCY1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

subdued-RA

FBtr0083805

NM_142563

4046

1075

subdued-RB

FBtr0083806

NM_169867

3531

926

subdued-RD

FBtr0302492

NM_001202319

4118

1099

subdued-RE

FBtr0334921

NM_001275807

3504

926

subdued-RF

FBtr0334922

NM_001275808

3603

950

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

subdued-PA

FBpp0083215

123.9

1075

6.98

FBpp0083216

107.6

926

6.90

FBpp0291654

126.7

1099

7.40

FBpp0306941

107.6

926

6.90

FBpp0306942

110.4

950

7.36

A0A0B4KGH4

NP_001262737

AGB96117

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

926 aa isoforms: subdued-PB, subdued-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\subdued using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.28

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | posterior

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

yolk nucleus

(Fisher et al., 2012)

embryonic stage 9 -- 10

yolk nucleus

(Fisher et al., 2012)

embryonic stage 11 -- 12

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

yolk nucleus

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

organism

(Jang et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{GawB}subdued^c240

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval central nervous system | restricted

(Jang et al., 2015)

larval multidendritic class III neuron

(Himmel et al., 2023)

third instar larval stage

larval multidendritic class IV neuron

(Jang et al., 2015)

adult stage

adult central nervous system | restricted

(Jang et al., 2015)

adult proventriculus | restricted

(Jang et al., 2015)

oviduct | restricted

(Jang et al., 2015)

spermatheca | restricted

(Jang et al., 2015)

adult Malpighian tubule | restricted

(Jang et al., 2015)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\subdued in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\subdued

View exonic expression by tissue for Dmel\subdued

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038721

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42340/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038721

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038721

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038721

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16718

Flygut - An atlas of the Drosophila adult midgut

FBgn0038721

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of subdued

Transgenic constructs containing regulatory region of subdued

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene partially disrupted in

Df(3R)PR29

(Radermacher et al., 2014)

Df(3R)subdued^KO

(Wong et al., 2013)

Gene disrupted in

Df(3R)Exel6184

(Himmel et al., 2023)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal

subdued^Δ5265

viable

subdued^EY09647

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

subdued^GD3674

viable, with Scer\GAL4^Mef2.PR

subdued^GD3674

viable, with Scer\GAL4^pnr-MD237

subdued^GD3674

viable, with Scer\GAL4^tin.CΔ4

subdued^GD3674

Sterility

Allele

fertile

subdued^EY09647

semi-sterile

subdued^Δ5265

Other Phenotypes

Allele

abnormal cold stress response | larval stage, with Scer\GAL4^19-12

subdued^GD3674

abnormal cold stress response | larval stage (with Df(3R)Exel6184)

subdued^MI15535

abnormal cold stress response | larval stage | recessive

subdued^MI15535

abnormal immune response

subdued^KO

abnormal neuroanatomy | adult stage | chemical conditional, with Scer\GAL4^Or42a.PF

subdued^GD3674

abnormal neurophysiology | larval stage, with Scer\GAL4^19-12

subdued^GD3674

abnormal pain response | adult stage (with Df(3R)Exel6184)

subdued^Δ5265

abnormal pain response | larval stage, with Scer\GAL4^109(2)80

abnormal pain response | larval stage, with Scer\GAL4^ppk.PG

abnormal pain response | larval stage, with Scer\GAL4^subdued-c240

abnormal pain response | larval stage (with Df(3R)Exel6184)

subdued^Δ5265

abnormal pain response | larval stage | recessive

subdued^Δ5265

some die during pupal stage

subdued^Δ5265

Phenotype manifest in

Allele

adult olfactory receptor neuron Or42a | chemical conditional, with Scer\GAL4^Or42a.PF

subdued^GD3674

larval multidendritic class III neuron, with Scer\GAL4^19-12

subdued^GD3674

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (11)

Hsap\ANO1

12 of 14

Yes

Hsap\ANO2

10 of 14

Yes

Hsap\ANO4

10 of 14

Hsap\ANO6

10 of 14

Yes

Hsap\ANO3

9 of 14

Hsap\ANO5

9 of 14

Hsap\ANO7

6 of 14

Yes

Hsap\ANO9

6 of 14

Yes

Hsap\ANO8

2 of 14

Hsap\ANO10

2 of 14

Hsap\LOC102723370

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (10)

Rnor\Ano1

12 of 14

Yes

Rnor\Ano6

10 of 14

Yes

Rnor\Ano2

9 of 14

Yes

9 of 14

8 of 14

8 of 14

7 of 14

Yes

Rnor\Ano9

5 of 14

Yes

Rnor\Ano8

2 of 14

Rnor\Ano10

2 of 14

Mus musculus (laboratory mouse) (10)

Mmus\Ano1

12 of 14

Yes

Mmus\Ano2

11 of 14

Yes

Mmus\Ano6

10 of 14

Yes

9 of 14

9 of 14

9 of 14

6 of 14

Yes

Mmus\Ano9

6 of 14

Yes

Mmus\Ano8

2 of 14

Mmus\Ano10

2 of 14

Xenopus tropicalis (Western clawed frog) (15)

Xtro\ano1

8 of 13

Yes

Xtro\ano3

7 of 13

Xtro\ano6

7 of 13

Xtro\LOC100498224

7 of 13

Yes

Xtro\ano2

6 of 13

Yes

Xtro\ano4

5 of 13

Yes

Xtro\ano5

4 of 13

Xtro\LOC101732476

4 of 13

Yes

Xtro\ano7

3 of 13

Yes

Xtro\LOC100490855

3 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100489387

1 of 13

Yes

Danio rerio (Zebrafish) (16)

Drer\ano1a

11 of 14

Yes

Drer\ano2b

10 of 14

Yes

Drer\ano6

10 of 14

Drer\ano3

9 of 14

Yes

Drer\ano5a

9 of 14

Drer\ano5b

9 of 14

Drer\ano11

7 of 14

Yes

Drer\ano7

6 of 14

Yes

Drer\ano9b

6 of 14

Yes

Drer\LOC563500

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\LOC101886884

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\anoh-1

9 of 14

Yes

Cele\anoh-2

2 of 14

Cele\F56A8.9

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP010474

6 of 12

Yes

Agam\AgaP_AGAP000095

5 of 12

Agam\AgaP_AGAP009776

2 of 12

Agam\AgaP_AGAP009995

2 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\AT1G73020

5 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\IST2

3 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPBC691.05c

5 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:subdued. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

CG6938

10 of 13

CG10353

10 of 13

Axs

5 of 13

wwk

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ANO6; anoctamin 6

model of Scott syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

12 of 14

10 of 14

10 of 14

10 of 14

SCOTT SYNDROME; SCTS

Scott syndrome

ANO3; anoctamin 3

9 of 14

610110

DYSTONIA 24; DYT24

dystonia 24

9 of 14

6 of 14

6 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67332

DroID - A comprehensive database of gene and protein interactions.

FBgn0038721

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-66

Cytogenetic map

92A11-92A11

Sequence location

3R:19,633,418..19,642,722 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

92A11-92A11

Limits computationally determined from genome sequence between P{EP}EP650 and P{PZ}l(3)10585¹⁰⁵⁸⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-66

(FlyBase, 2016)

3-68.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

85569

w¹¹¹⁸; PBac{RB}subdued^e02779

61082

y¹ w^*; Mi{MIC}subdued^MI15535

20046

y¹ w^67c23; P{EPgy2}subdued^EY09647

14028

y¹ w^67c23; ry⁵⁰⁶ P{SUPor-P}subdued^KG06218

52197

y¹ w^*; Mi{MIC}subdued^MI09704/TM3, Sb¹ Ser¹

97156

y¹ w^*; TI{CRIMIC.TG4.0}subdued^{CR70150-TG4.0}; l(3)*^*/TM6B, Tb¹

Kyoto

123409

w¹¹¹⁸; P{RS3}subdued^CB-5010-3

125540

w¹¹¹⁸; P{RS5}subdued^5-HA-2055

VDRC

v108953

P{KK102353}VIE-260B

v37472

w¹¹¹⁸; P{GD3674}v37472

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (48)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038721

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038721

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

subdued is a chloride channel that is activated by both noxious heat and intracellular Ca[2+]. It is required for thermal nociception.

(Jang et al., 2015)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: subdued CG16718

(Wong et al., 2013)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG16718

(Jang et al., 2015, Radermacher et al., 2014, Wong et al., 2013, Remolina et al., 2012, Cernilogar et al., 2011, Kong et al., 2010, Wasbrough et al., 2010, Keleman et al., 2009.8.5, Zsindely et al., 2009, Bushati et al., 2008, Lin et al., 2007)

Subdued

(Montell, 2021)

subdued

(Himmel et al., 2023, Dow et al., 2021, Roy Choudhury et al., 2021, Geigges et al., 2020, Gene Disruption Project members, 2018-, Onodera et al., 2017, Jang et al., 2015)

Name Synonyms

Subdued

(Le et al., 2019)

subdued

(Yoshino et al., 2025, Ghavi-Helm et al., 2019, Wong et al., 2013)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 60 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42340

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4JCY1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4JCY1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038721

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42340/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038721

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038721

FlyMine - An integrated database for Drosophila genomics

FBgn0038721

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG16718

MARRVEL_MODEL - MARRVEL (model organism gene)

42340

Linkouts

BioGRID - A database of protein and genetic interactions.

67332

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038721

DroID - A comprehensive database of gene and protein interactions.

FBgn0038721

DRSC - Results frm RNAi screens

FBgn0038721

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038721

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038721

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16718

Flygut - An atlas of the Drosophila adult midgut

FBgn0038721

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

References (52)

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