FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ind10A013
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General Information
Symbol
Dmel\ind10A013
Species
D. melanogaster
Name
FlyBase ID
FBal0303669
Feature type
allele
Associated gene
Dmel\ind
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Thor, 2015.4.2)
Mutagen
ethyl methanesulfonate
(Thor, 2015.4.2)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C836T.

(Bivik et al., 2015)

Amino acid replacement: R279Q.

(Bivik et al., 2015)

The mutation introduces a stop codon in the region encoding the homeodomain; consequently, it is likely a strong loss-of-function allele.

(Thor, 2015.4.2)

Amino acid replacement: ??term.

(Thor, 2015.4.2)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:15,043,029..15,043,029 [-]
Nucleotide change:

G15043029A

Reported nucleotide change:

C836T

Amino acid change:

R279Q | ind-PB

Reported amino acid change:

R279Q

Comment:

The reported nucleotide change is relative to the non-coding strand.

(Bivik et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show two or more cells (rather than one cell) in the same thoracic hemisegment expressing P{FMRFa-EGFP.Tv}, a marker for the six Ap4 neurons in the developing ventral nerve cord, and extra expression of eya, which identifies the four Ap cluster neurons.

      (Bivik et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ind16.2

      (Bivik et al., 2015)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Isolated in a screen for altered expression of P{FMRFa-EGFP.Tv}, which is normally expressed in only six cells of the ventral nerve cord. It was mapped to the ind gene via whole-genome sequencing, deletion mapping and complementation tests with mutant alleles.

      (Thor, 2015.4.2)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ind10A013
      (Bivik et al., 2015, Thor, 2015.4.2)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)