FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4Gr64a-GAL4
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General Information
Symbol
Scer\GAL4Gr64a-GAL4
Species
S. cerevisiae
Name
FlyBase ID
FBal0304297
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
TI{GAL4}Gr64aGAL4
Carried in Construct
Also Known As
Gr64aGAL4
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gene targeting by homologous recombination
(Fujii et al., 2015)
Progenitor genotype
Associated Insertion(s)
TI{GAL4}Gr64aGAL4
Cytology
Description

The Gr64a coding sequences have been replaced with sequence encoding a GAL4 driver.

(Fujii et al., 2015)

The Gr64a coding sequences have been replaced with sequence encoding a GAL4 driver. A single loxP site is also present downstream of the inserted driver sequence

(Yavuz et al., 2014)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      prothoracic leg taste bristle chemosensory neuron | subset of tarsal segment 4
      (Fujii et al., 2015)
      prothoracic leg taste bristle chemosensory neuron | subset of tarsal segment 5
      (Fujii et al., 2015)
      sugar-sensing neuron of taste bristle | subset of prothoracic leg taste bristle chemosensory neuron
      (Fujii et al., 2015)
      gustatory receptor neuron | subset of labral sense organ neuron
      (Fujii et al., 2015)
      posterior superior lateral protocerebrum | restricted
      (Fujii et al., 2015)
      adult brain | restricted
      (Fujii et al., 2015)
      Additional Information
      Statement
      Reference

      ScerGAL4Gr64a-GAL4 drives expression in 3 (of 4) prothoracic leg tarsal taste bristles in tarsal segment 5, 4 gustatory receptor neurons of the adult labral sense organ, 4 neurons in the posterior superior lateral protocerebrum and a single neuron in the anterior dorsolateral region of the brain. Expression partially overlaps with that of EcollexAVP16.Gr43a in these latter two regions. It does not drive expression in the S cells of the labellar taste bristles, in contrast to all other related sweet sensing gustatory receptor genes.

      (Fujii et al., 2015)
       
      Marker for
      Reflects expression of
      Gr64a
      (Fujii et al., 2015)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Hsap\KCNJ2IVS.10xUAS.EGFP) of Scer\GAL4Gr64a-GAL4 cells in adult females results in a significant increase in preference for softer 100 mM sucrose-containing agarose for egg laying, compared to controls.

      (Wu et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gr64aGAL4
      (Shrestha et al., 2023, Chen et al., 2022, Wu et al., 2019, Fujii et al., 2015)
      Scer\GAL4Gr64a-GAL4
      Name Synonyms
      Secondary FlyBase IDs
        References (5)