FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SnapinGD12574
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General Information
Symbol
Dmel\SnapinGD12574
Species
D. melanogaster
Name
FlyBase ID
FBal0304567
Feature type
allele
Associated gene
Dmel\Snapin
Associated Insertion(s)
Carried in Construct
P{GD12574}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickman et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickman et al., 2012)
Mutagen
in vitro construct
(Dickman et al., 2012)
Progenitor genotype
Carried in construct
P{GD12574}
Cytology
Description

UASt regulatory sequences drive expression of an RNAi construct which targets sequence encoding the CG9960 open reading frame (ORF). This ORF is part of a dicistronic transcript that encodes both Snapin and CG9960, and expression of both these genes is down-regulated by this RNAi construct.

(Dickman et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD12574
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The presynaptic homeostatic plasticity that normally occurs after application of the postsynaptic glutamate receptor antagonist PhTx is blocked in larvae expressing P{GD12574} (which down-regulates expression of both Snapin and CG9960) in the nervous system (under the simultaneous control of both Scer\GAL4elav-C155 and Scer\GAL4sca.PC). This defect is due to the knock-down of Snapin (and not of CG9960), since co-expression of SnapinScer\UAS.cDa rescues this defect.

      Presynaptic homeostatic plasticity after application of PhTx is normal in larvae expressing P{GD12574} in the muscle (using Scer\GAL4Mhc.PU).

      (Dickman et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The developmental homeostatic plasticity that normally occurs in larvae expressing GluRIICdsRNA.Scer\UAS.cFa in the muscle under the control of Scer\GAL4C57 is completely blocked if the larvae are also expressing P{GD12574} in the nervous system (under the simultaneous control of both Scer\GAL4elav-C155 and Scer\GAL4sca.PC).

      The potentiation of baseline release that is seen in larvae expressing DysbScer\UAS.cDa under the control of Scer\GAL4elav-C155 is no longer seen if the animals are also expressing P{GD12574} under the simultaneous control of both Scer\GAL4elav-C155 and Scer\GAL4sca.PC.

      (Dickman et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SnapinGD12574
      Name Synonyms
      Secondary FlyBase IDs
        References (3)