FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\X11LβRNAi.UAS
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General Information
Symbol
Dmel\X11LβRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0304610
Feature type
allele
Associated gene
Dmel\X11Lβ
Associated Insertion(s)
Carried in Construct
P{UAS-X11Lβ.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Gross et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Gross et al., 2013)
Mutagen
in vitro construct
(Gross et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-X11Lβ.RNAi}
Cytology
Description

The coding region and 5'UTR of X11Lβ are targeted with microRNA technology to silence X11Lβ. These miRNA are cloned downstream of UAS regulatory sequences.

(Gross et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
X11Lβ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Downregulation of X11Lβ, through expression of X11LβdsRNA.Scer\UAS under the control of Scer\GAL4elav.PU results in viable flies and adults that are wild-type in appearance.

      Expression of X11LβdsRNA.Scer\UAS under the control of the mushroom body driver Scer\GAL4ey-OK107 does not cause structural phenotypes in the larval mushroom body. However, lobe defects are seen in the adult brain.

      (Gross et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pan-neuronal silencing of X11LdsRNA.Scer\UAS.cGa and X11LβdsRNA.Scer\UAS, under the control of Scer\GAL4elav.PU results in early to mid-third instar larval lethality.

      Pan-neuronal silencing of X11LβdsRNA.Scer\UAS under the control of Scer\GAL4elav.PU, in a X11L80 homozygous background results in early to mid-third instar larval lethality.

      (Gross et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      X11LβRNAi.UAS
      X11LβdsRNA.Scer\UAS
      X11LβdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)