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General Information
Symbol
Dmel\X11L80
Species
D. melanogaster
Name
FlyBase ID
FBal0304609
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EPg}HP10026 from the 5'UTR of X11L generates a X11L deletion mutant.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

X11L80 mutants are viable and adults are wild-type in appearance.

X11L80 mutant mushroom body lobes exhibit mislocalised multiple axonal membrane proteins and lobe structural defects. The dorsal lobe is aberrantly formed, causing it to be severely truncated. In addition, the medial lobe appears frayed and misshapen, indicating abnormal axon development.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Pan-neuronal silencing of X11LβdsRNA.Scer\UAS under the control of Scer\GAL4elav.PU, in a X11L80 homozygous background results in early to mid-third instar larval lethality.

A AP-2α06694 homozygous mutant background enhances the dendritic mislocalisation of axonal membrane proteins and structural defects in the mushroom body of X11L80 mutants.

Xenogenetic Interactions
Statement
Reference

Expression of Hsap\APBA2Scer\UAS.cHa under the control of Scer\GAL4elav.PU, partially rescues the axonal membrane protein mislocalisation and structural defects seen in the mushroom body of X11L80 mutants.

Complementation and Rescue Data
Partially rescued by
Comments

Expression of X11LScer\UAS.cGa under the control of Scer\GAL4elav.PU, partially rescues the axonal membrane protein mislocalisation and structural defects seen in the mushroom body of X11L80 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
X11L80
Name Synonyms
Secondary FlyBase IDs
    References (1)