FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\foxoNK.UAS
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General Information
Symbol
Dmel\foxoNK.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0305271
Feature type
allele
Associated gene
Dmel\foxo
Associated Insertion(s)
Carried in Construct
PBac{UAS-foxo.NK}
Key Links
Transgenic product class
missense_variant
(Koyama et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Koyama et al., 2014)
Mutagen
in vitro construct
(Koyama et al., 2014)
Progenitor genotype
Carried in construct
PBac{UAS-foxo.NK}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of foxo containing two mutations, N175A and K204A.

(Koyama et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
foxo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of foxoNK.Scer\UAS under the control of Scer\GAL4C-765 and Scer\GAL4Bx-MS1096 in the wing, and Scer\GAL4ey.PU and Scer\GAL4GMR.PU in the eye results in reduced organ size compared to controls.

      Expression of foxoNK.Scer\UAS under the control of Scer\GAL4phm.PO results in starved larvae that undergo the 'critical weight' ecdysone peak late and at smaller sizes than in parental controls but earlier than in flies expressing wild type foxo (foxoScer\UAS.cKc). Pupae are larger than parental controls, but smaller than those expressing foxoScer\UAS.cKc.

      foxoΔ94/Df(3R)Exel8159 mutant starved larvae that express foxoNK.Scer\UAS under the control of Scer\GAL4phm.PO reach the 'critical weight' ecdysone peak later and at larger sizes than controls, but earlier and at smaller sizes than larvae that express foxoScer\UAS.cKc.

      Prothoracic gland size is reduced in larvae expressing foxoScer\UAS.cKc under the control of Scer\GAL4P0206 to a similar extent to larvae expressing foxoScer\UAS.cKc.

      (Koyama et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expressing foxoNK.Scer\UAS and uspScer\UAS.cUa under the control of Scer\GAL4phm.PO in foxoΔ94/Df(3R)Exel8159 mutant larvae does not alter the age and size of the 'critical weight' ecdysone peak, nor does it alter final body size when compared to overexpressing foxoNK.Scer\UAS alone.

      (Koyama et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      foxoNK.Scer\UAS
      foxoNK.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)