FlyBase Allele Report: Dmel\Pi3K92E[HMC05152]

General Information

Symbol

Dmel\Pi3K92E^HMC05152

Species

D. melanogaster

Name

FlyBase ID

FBal0314964

Feature type

allele

Associated gene

Dmel\Pi3K92E

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC05152}

Also Known As

Pi3K92E RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC05152}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC05152

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates prostate cancer

modeled by Ras85D^V12.UAS

(Rambur et al., 2020)

ameliorates carcinoma

modeled by yki^HMS00041

(Bhattacharya et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Tamada et al., 2021)

Phenotype Manifest In

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Tamada et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pi3K92E^HMC05152, Scer\GAL4^en-e16E is a suppressor of increased cell death | third instar larval stage phenotype of Pten^HMS00044, Scer\GAL4^en-e16E

(Sun et al., 2020)

Pi3K92E^HMC05152, Scer\GAL4^en-e16E is a suppressor of increased size | third instar larval stage phenotype of Pten^HMS00044, Scer\GAL4^en-e16E

(Sun et al., 2020)

Pi3K92E^HMC05152, Scer\GAL4^NP0001 is a suppressor of increased cell size phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Pi3K92E^HMC05152, Scer\GAL4^en-e16E is a suppressor of wing disc | third instar larval stage phenotype of Pten^HMS00044, Scer\GAL4^en-e16E

(Sun et al., 2020)

Pi3K92E^HMC05152, Scer\GAL4^en-e16E is a suppressor of wing disc posterior compartment | third instar larval stage phenotype of Pten^HMS00044, Scer\GAL4^en-e16E

(Sun et al., 2020)

Pi3K92E^HMC05152, Scer\GAL4^NP0001 is a suppressor of adult midgut epithelium phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Pi3K92E^HMC05152 suppresses the increased midgut cell size resulting from the expression of Atg9^HMS01246 under the control of Scer\GAL4^{Myo31DF-NP0001}.

(Wen et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

61182

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05152}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PI3K^RNAi

(Wen et al., 2017)

Pi3K92E^HMC05152

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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